Imaging Effects of Netarsudil (Rhopressa) in Glaucoma and Ocular Hypertension

This study is looking at how Netarsudil (Rhopressa), an FDA-approved eye drop for glaucoma, affects the eye's drainage system (trabecular meshwork). You could join if you are an adult with ocular hypertension or open-angle glaucoma and have good vision. Participants will either receive Netarsudil or artificial tears for about 14 days. Researchers will use special imaging to see if Netarsudil changes the spacing of the trabecular meshwork. The study aims to enroll about 50 people, but its current status is unclear.

Study design
This is a randomized, single-masked study, meaning you won't know if you're getting Netarsudil or artificial tears. About 50 participants will be enrolled.
What's involved
You would use eye drops once daily in the evening for about 14 days. You will have eye imaging at the beginning and after about 14-21 days of treatment.
Compensation
Not stated in the trial record.
Follow-up
Your eye will be imaged at baseline and again 14-21 days after starting treatment.

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NCT07588152

Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension

Recruiting
PHASE4Ages 18+InterventionalBasic science
Indiana University
~50 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:Netarsudil Ophthalmic Solution (Rhopressa)Artificial Tears (AT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Trabecular Meshwork Lamellae Spacing
Measured over Baseline to 14-21 days after initiation of treatment
Glaucoma
Ocular Hypertension
1 sites across 1 states
Indiana1

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Eligibility criteria

Inclusion

Adults aged 18 years or older
Diagnosis of ocular hypertension or open-angle glaucoma
Eye examination within the past year
For glaucoma subjects: structural (optic nerve and/or retinal nerve fiber layer) and functional (visual field) findings consistent with glaucoma
Best-corrected visual acuity of 20/100 or better
Open anterior chamber angle as confirmed by gonioscopy and anterior segment optical coherence tomography (AS-OCT)
Intraocular pressure between 18 and 34 mmHg (treatment-naïve or after washout, if applicable)

Exclusion

Known intolerance to netarsudil ophthalmic solution
Corneal scarring or active corneal disease that would interfere with imaging
Inability to tolerate gonioscopy procedures
Females of childbearing potential who are not using effective contraception or are not sterile
Any condition that, in the opinion of the investigator, would place the subject at increased risk or interfere with study completion
  • Change in Trabecular Meshwork Lamellae SpacingBaseline to 14-21 days after initiation of treatment

    Mean change in trabecular meshwork lamellae spacing measured using adaptive optics gonioscopy. Measurements will be obtained from baseline (after washout if applicable) and compared to measurements after treatment.