A Study on Weight Management for Obesity or Overweight

This study is looking into how well macupatide and eloralintide, either alone or together, can help adults with obesity or who are overweight manage their weight. Researchers will compare these treatments to a placebo (an inactive substance) to see if they help people lose weight and if they are safe. You might be able to join if you are between 18 and 75 years old and have obesity or are overweight, but you cannot have type 1 or type 2 diabetes. The main goal is to see the percentage of body weight change after 36 weeks. The current status of this study is unclear.

Study design
This interventional study plans to include 400 adult participants. It will compare macupatide and eloralintide, alone or in combination, against a placebo.
What's involved
Your participation in this study will last for about 64 weeks. The primary measurement of your body weight change will be taken at the beginning and at Week 36.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for measuring body weight change is at Week 36.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07589608

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Eli Lilly and Company
~400 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:MacupatideEloralintidePlacebo

At a glance

Recruiting sites
40 of 40 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Change from Baseline in Body Weight
Measured over Baseline, Week 36
Overweight
Obesity
40 sites across 20 states
Florida5
Texas5
California4
North Carolina4
Arizona3
Massachusetts2
Michigan2
Missouri2
  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Have type 1 diabetes or type 2 diabetes
Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
Have a history of acute or chronic pancreatitis
All concomitant medications should be at a stable dose for at least 3 months prior to screening
  • Percent Change from Baseline in Body WeightBaseline, Week 36