This study is looking for Veterans aged 25-65 with high levels of PFAS (per- and polyfluoroalkyl substances) in their blood. The goal is to see if a medication called Colesevelam can help lower these PFAS levels. You would take Colesevelam or a placebo (an inactive pill) for 12 weeks. After this, those who received the placebo might get the chance to take Colesevelam. We will measure your PFAS levels at 24 weeks to see if the treatment was successful. The study aims to enroll about 50 participants, but the current status of enrollment is unclear.

Study design

This is a double-blind, randomized controlled trial, meaning neither you nor your doctor will know if you are receiving Colesevelam or a placebo. The study plans to enroll 50 participants.

What's involved

You would take oral Colesevelam (3 x 625 mg tablets daily) or a placebo for 12 weeks. If you were on placebo, you might then take Colesevelam for another 12 weeks, while those on Colesevelam would continue for 24 more weeks.

Compensation

Not stated in the trial record.

Follow-up

Your PFAS levels will be measured at 24 weeks to assess the study's primary outcome.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.