Back to search results

Observational Study on Heart Disease Risk in Childhood Cancer Survivors

This study is looking at heart and blood vessel health in adult survivors of childhood cancer, who may be at higher risk for heart disease (atherosclerotic cardiovascular disease or ASCVD) due to past treatments like radiation or platinum chemotherapy. Researchers will use several diagnostic tests, including a Coronary Artery Calcium Scan (a special CT scan of your heart), Carotid Artery Ultrasound (an ultrasound of the arteries in your neck), and a blood test to measure Lipoprotein(a) (a fat-like substance in your blood). They will also perform Vascular Function Testing to check the stiffness of your arteries. The goal is to understand the prevalence of abnormal heart and blood vessel findings in survivors compared to people who haven't had cancer, to help develop better prevention strategies. This study is for adults aged 18 and older who are part of the St. Jude Lifetime Cohort (SJLIFE).

Study design
This is an observational study, meaning participants will be carefully monitored and tested, but no new treatments are given. It plans to enroll 650 participants.
What's involved
You would undergo a Coronary Artery Calcium Scan, Carotid Artery Ultrasound, a blood draw for Lipoprotein(a) Measurement, and Vascular Function Testing. The duration of these commitments is not specified.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, which measure the prevalence of abnormal coronary artery calcium score and carotid stenosis, are measured at Baseline. Further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07594392

Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE

Not Yet Recruiting
Not specifiedAges 18+Observational
St. Jude Children's Research Hospital
~650 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Coronary Artery Calcium ScanCarotid Artery UltrasoundLipoprotein(a) MeasurementVascular Function Testing

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine the prevalence of abnormal coronary artery calcium score among survivors with cancer treatment exposures associated with increased risk for ASCVD and ischemic heart disease overall and in comparison to community controls.
Measured over Baseline
+1 more outcome measured

Conditions

Atherosclerotic Cardiovascular Disease

Explore related trials

AtherosclerosisChildhood Malignant Neoplasm

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Stephanie B Dixon, MD, MPH · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital

Who to contact

Stephanie B Dixon, MD, MPH
[email protected]
888-226-4343
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age ≥18 years
Enrolled in the St. Jude Lifetime Cohort (SJLIFE)
Participant or legal guardian/representative is able and willing to give informed consent.
Participant has been treated with at least one of the following cancer therapies:

Exclusion

Previous stroke or intervention for severe carotid arterial disease including carotid endarterectomy or carotid angioplasty and stent placement.
Previous myocardial infarction or intervention for severe cardiovascular disease including Coronary Artery Bypass Graft (CABG), coronary stent placement or coronary angioplasty.
History of aortic valve replacement
Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
First degree relative of SJLIFE Survivor
History of cancer

What this trial measures

  • Determine the prevalence of abnormal coronary artery calcium score among survivors with cancer treatment exposures associated with increased risk for ASCVD and ischemic heart disease overall and in comparison to community controls.Baseline

    Coronary artery calcium (CAC) score (Agatston score) reported as a whole number and then categorized as abnormal first as CAC\>0 and then as CAC\>100.

  • Determine the prevalence of carotid stenosis using carotid ultrasound among survivors with cancer treatment exposures associated with increased risk for ASCVD and stroke overall in comparison to community controls.Baseline

    Carotid artery stenosis as a percentage (%) and then as abnormal (Y/N) with abnormal considered stenosis at least 50% in either the L or R carotid artery.