A Study of Ivonescimab in People With Non-Small Cell Lung Cancer

This study is looking at whether a drug called ivonescimab, given after standard radiation therapy (stereotactic body radiotherapy or SBRT), is an effective treatment for people with early-stage non-small cell lung cancer (NSCLC). Researchers want to see if ivonescimab can help you live longer without your cancer coming back. You might be able to join if you have NSCLC that is stage IA2-IIA, or certain stage IIB, and are at least 18 years old. The study is currently recruiting a small group of 36 participants.

Study design
This study plans to enroll 36 participants. It is an interventional study, meaning participants will receive a specific treatment.
What's involved
You would receive radiation therapy within 28 days of joining, followed by ivonescimab given intravenously (IV) every 3 weeks.
Compensation
Not stated in the trial record.
Follow-up
Researchers will follow participants for 24 months to measure how long they live without their cancer returning.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07594522

A Study of Ivonescimab in People With Non-Small Cell Lung Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
Memorial Sloan Kettering Cancer Center
~36 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Photon or Proton standard stereotactic body radiotherapy (SBRT)Ivonescimab

At a glance

Recruiting sites
7 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
24-month event-free survival
Measured over 24 months
Non-Small Cell Lung Cancer
7 sites across 2 states
New York4
New Jersey3
  • Narek Shaverdian, MD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

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  • 24-month event-free survival24 months

    Event-free survival will include any disease progression (local, nodal, regional, distant, defined by RECIST 1.1),