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E-Cigarette Flavors and Opioid Use Disorder Study

This study looks at how different e-cigarette (EC) flavors affect adults who use e-cigarettes and have opioid use disorder (OUD). You can join if you are 21 or older, currently use e-cigarettes often, used to smoke cigarettes daily but now smoke less, and are receiving buprenorphine treatment for OUD. The study will have you smell and rate 11 EC flavors, including Sweet-cooling EC flavor, Sweet non-cooling EC flavor, and Tobacco flavor EC. Researchers want to see which flavors you find appealing and how they might help make e-cigarettes a useful tool for reducing harm in people with OUD. The main goals are to measure how sweet, cool/fresh, and strong you perceive these flavors to be at the start of the study.

Study design
This is an observational study aiming to enroll 70 participants. It is not a randomized trial and does not involve a specific phase of drug development.
What's involved
You will complete a brief session where you smell and rate 11 e-cigarette flavors based on their appeal, sensory qualities, and how likely you would be to use them in the future.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07594717

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

Completed
Not specifiedAges 21+Observational
Prisma Health-Upstate
~70 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Sweet-coolingSweet non-cooling EC flavorTobacco flavor EC

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Perceived Sweetness
Measured over Baseline session
+5 more outcomes measured

Conditions

Nicotine Use Disoder
Opioid Use Disorder

Explore related trials

Nicotine use disorderOpioid Use Disorder

Where it's being run

1 sites across 1 states
South Carolina1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults aged 21 years or older.
Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days.
Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day.
Diagnosed with opioid use disorder (OUD).
Currently receiving buprenorphine treatment for OUD.

What this trial measures

  • Perceived SweetnessBaseline session

    Perceived sweetness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not sweet at all" to "Extremely sweet," with higher scores indicating greater perceived sweetness.

  • Perceived Coolness/FreshnessBaseline session

    Perceived coolness/freshness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not cool/fresh at all" to "Extremely cool/fresh," with higher scores indicating greater perceived coolness/freshness.

  • Perceived Flavor StrengthBaseline session

    Perceived flavor strength will be assessed using a one-item VAS ranging from "Very weak" to "Very strong," with higher scores indicating greater perceived flavor strength.

  • Perceived Harshness/IrritationBaseline session

    Perceived harshness/irritation of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not harsh/irritating at all" to "Extremely harsh/irritating," with higher scores indicating greater perceived harshness/irritation.

  • Flavor LikingBaseline session

    Flavor liking will be assessed using a one-item VAS ranging from "Not at all" to "Extremely," with higher scores indicating greater liking of the flavor.

  • Likelihood of Future UseBaseline session

    Likelihood of future use will be assessed using a one-item VAS ranging from "Not at all" to "Definitely," with higher scores indicating greater likelihood of future use of the flavor.