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Study 1.3: Non-invasive Deep Brain Stimulation with Temporal Interference Methods

This study is testing a new way to stimulate deep parts of the brain without surgery, called Temporal Interference (TI) Electrical Stimulation. Researchers want to see how TI Electrical Stimulation affects brain activity in healthy volunteers aged 18 to 50. You would receive different types of TI Electrical Stimulation, some active and some sham (inactive), to see how your brain responds. The main goal is to measure changes in brain activity in a specific area called the dorsal anterior cingulate cortex (dACC) during the stimulation. This research aims to understand how TI works and could eventually lead to new treatments for conditions like addiction or OCD. The study is currently unclear on its recruitment status and plans to enroll 30 participants.

Study design
This interventional study plans to enroll 30 healthy volunteers. It compares different types of Temporal Interference (TI) Electrical Stimulation, including active and sham conditions.
What's involved
The primary endpoint involves measuring brain activity during an fMRI scan, which takes approximately 60 minutes on a study day.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured during an fMRI scan on a study day, which lasts approximately 60 minutes. Longer-term follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07594795

Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3

Recruiting
NAAges 18–50InterventionalBasic science
Indiana University
~30 participants
Updated 2026-09-11 on ClinicalTrials.gov
What's tested:Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI ActiveTemporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI ShamTemporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI ActiveTemporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Sham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in brain activity in the dorsal anterior cingulate cortex during 20 Hz versus selected comparison frequency temporal interference stimulation
Measured over During fMRI scan on study day (approximately 60 minutes)

Conditions

Healthy Volunteers

Explore related trials

Healthy Volunteers

NCT07594795

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Indiana University Bloomington, Imaging Research Facility

    Bloomington, Indianastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Joshua W Brown, PhD · PRINCIPAL_INVESTIGATOR · Indiana University, Bloomington

Who to contact

Joshua W Brown, PhD
[email protected]
812-855-9282
Email the study team

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Eligibility criteria

Inclusion

Between the ages of 18 and 50
Must have at least a 6th grade education
Ability to speak and read English for all phases

Exclusion

Currently taking psychotropic medications for ADHD, other mental illness, or medications for cancer
History of epilepsy or seizure disorders
History of migraines or other neurological syndromes
History of AIDS (due to potential cognitive deficits)
History of head trauma or cognitive impairments
Personal experiences consistent with symptoms of psychosis (e.g., hallucinations, delusions of control or special powers)
History of skull defects (e.g., holes bored into the skull or known cranial fissures)
Metal implants in the head or under the scalp
Does not meet fMRI safety screening criteria (e.g., metal implants in the body, permanent jewelry, tattoos on the head or neck)
Uses an intrauterine device (IUD) for birth control and cannot provide documentation to verify MRI safety
Pregnancy (self-reported; no pregnancy test administered)
Weight over 440 lbs (scanner weight limit)
Presence of pacemakers

What this trial measures

  • Change in brain activity in the dorsal anterior cingulate cortex during 20 Hz versus selected comparison frequency temporal interference stimulationDuring fMRI scan on study day (approximately 60 minutes)

    Brain activity in the dorsal anterior cingulate cortex will be measured using functional magnetic resonance imaging (fMRI) during temporal interference (TI) stimulation at 20 Hz compared to a selected comparison beat frequency. The comparison frequency will be in the 1-100 Hz range. Activity will be reported as the percent change in blood-oxygen-level-dependent (BOLD) signal, which reflects changes in neural activity. Higher BOLD values indicate stronger brain activation.