This study is testing a new way to treat infected knee replacements. If you have an infected knee replacement, you might be eligible. All participants will receive standard surgery for their infection. Half of the participants will also receive an injection of Definity microbubbles and antibiotics into the knee after surgery. Ultrasound will then be used to break up these microbubbles, which researchers hope will make the antibiotics work better. The main goal is to see if this extra treatment can reduce the rate of re-infection by at least 24% over two years. The study aims to enroll 100 people and is currently unclear on its recruitment status.

Study design

This is an interventional study with 100 planned participants. Participants will be randomly divided into two groups: one receiving standard care and the other receiving standard care plus the microbubble treatment.

What's involved

You will undergo revision surgery for your infected knee replacement. If in the active group, you will receive an injection of Definity microbubbles and antibiotics within 24 hours of surgery, followed by ultrasound treatment.

Compensation

Not stated in the trial record.

Follow-up

Your re-infection rate will be measured at 2 years after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.