Light Therapy for Sleep in Traumatic Brain Injury
This study is looking at how Morning Bright Light Therapy and Negative Ion Generator Therapy might improve sleep in people who have had a traumatic brain injury (TBI). Researchers want to see if better sleep can improve important body processes related to brain health, such as how cells produce energy (mitochondrial function), body-wide inflammation, and the brain's waste removal system (glymphatic function). You might be able to join if you are between 18 and 89 years old, speak English, and do not have certain eye conditions or bipolar disorder. The study aims to understand changes in blood markers of inflammation, mitochondrial function, and glymphatic function over about four weeks of using the device.
- Study design
- This is an interventional study planning to enroll 300 participants. It is designed to explore the effects of light therapy on brain health.
- What's involved
- Participants will use a device for approximately four weeks. During this time, blood samples will be taken, mitochondrial function will be measured, and brain imaging (MRI) will be performed.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken from before the intervention to the end of device use, which is approximately 4 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Define the profile of blood-based markers of systemic inflammation pre- vs post-MBLT.From pre-intervention to end of device use (Approximately 4 weeks).
The primary outcome defines the pre- to post-intervention change in inflammatory target expression using NULISA proteomics (reporting proteins as NPQ relative units).
- Define mitochondrial function (oxygen consumption rate via Seahorse) pre- vs. post-MBLT.From pre-intervention to end of device use (Approximately 4 weeks).
The primary outcome of this aim reflects pre- to post-intervention change in mitochondrial bioenergetics. Specific metrics include basal oxygen consumption rate, maximal oxygen consumption rate, and spare/reserve capacity (difference between maximal and basal oxygen consumption rate).
- Explore glymphatic function via novel multi-model non-contrast-based MRI pre- vs. post-MBLT.From pre-intervention to end of device use (Approximately 4 weeks).
The primary outcome defines pre- to post-intervention change in MRI visibler perivascular space burden (PVS number/volume).