Ketogenic Diet and Alcohol Intoxication Study

This study is looking at how a ketogenic diet (a diet very low in carbohydrates) affects your brain and how your body reacts to alcohol. Researchers want to see if the ketogenic diet changes the levels of a brain chemical called glutamate. You might be able to join if you are between 21 and 50 years old and have had at least two alcoholic drinks on a single day in the past month. The study involves following a ketogenic diet for about four weeks. The main goal is to measure changes in brain glutamate levels after four weeks on the diet. The current recruitment status is unclear, and they plan to enroll 20 people.

Study design
This is an interventional study, meaning you will receive a specific intervention (the ketogenic diet). It plans to enroll 20 participants.
What's involved
You would follow a ketogenic diet for about four weeks and attend three lab visits. These visits include alcohol tolerance tests, blood draws, and two MRI (Magnetic Resonance Imaging) scans.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 4 weeks, which is the duration of the diet intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07602270

Effects of Ketogenic Diet on Alcohol Intoxication

Recruiting
NAAges 21–50InterventionalBasic science
University of Pennsylvania
~20 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Ketogenic diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effects of ketogenic diet on cerebral levels of glutamate.
Measured over 4 weeks
Ketogenic Diet
Alcohol Drinking
Alcohol Use Disorder
Magnetic Resonance Imaging
Alcohol Intoxication
1 sites across 1 states
Pennsylvania1
  • Corinde Wiers, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
  • Henry Kranzler, MD · STUDY_DIRECTOR · University of Pennsylvania

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  • Effects of ketogenic diet on cerebral levels of glutamate.4 weeks

    Glutamate levels will be measures with magnetic resonance imaging prior to and after the 4 week ketogenic diet.