The BRIDGE Pain Study for Musculoskeletal Pain
The BRIDGE Pain Study is looking for young people aged 14 to 26 who have long-lasting muscle and bone pain, such as from Juvenile Idiopathic Arthritis (JIA), Fibromyalgia, Lupus, Scoliosis, or Pectus Excavatum. This is an observational study, meaning you won't receive any new treatments. Instead, researchers want to understand different types of musculoskeletal pain. They will look at your medical history, how your body senses pain (Conditioned Pain Modulation and Temporal Summation), and immune system markers in your blood. The goal is to identify at least two distinct pain subtypes based on how your brain and immune system affect pain, as well as your biology, psychology, and social environment. This study aims to enroll 600 participants.
- Study design
- This is an observational study, not testing a specific intervention. It aims to enroll 600 participants to understand different types of musculoskeletal pain.
- What's involved
- Researchers will collect information on your childhood medical history, past treatments, when your pain started, and what your pain feels like now. They will also perform tests to see how your body senses pain and collect blood samples for immune system markers.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints, which measure how your body senses pain, are taken at Baseline. The record does not specify any follow-up after this initial assessment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The BRIDGE Pain Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Conditioned Pain Modulation (CPM) Profile (Pressure)Baseline
CPM is defined by the change in pressure thresholds (increase) before and during cold immersion. Pressure thresholds will be measured using an algometer.
- Conditioned Pain Modulation (CPM) Profile (Heat)Baseline
CPM is defined by the change in heat pain intensity (decrease) before and during cold immersion. Heat stimuli will be delivered by a thermode and pain intensity measured by participant self report on the visual analog scale.
- Temporal Summation (TS) ProfileBaseline
TS is defined by the change in mechanical pain intensity (increase) after exposure to a series of pinprick stimuli. Pain intensity will be measured by participant self report on the visual analog scale.