The BRIDGE Pain Study for Musculoskeletal Pain

The BRIDGE Pain Study is looking for young people aged 14 to 26 who have long-lasting muscle and bone pain, such as from Juvenile Idiopathic Arthritis (JIA), Fibromyalgia, Lupus, Scoliosis, or Pectus Excavatum. This is an observational study, meaning you won't receive any new treatments. Instead, researchers want to understand different types of musculoskeletal pain. They will look at your medical history, how your body senses pain (Conditioned Pain Modulation and Temporal Summation), and immune system markers in your blood. The goal is to identify at least two distinct pain subtypes based on how your brain and immune system affect pain, as well as your biology, psychology, and social environment. This study aims to enroll 600 participants.

Study design
This is an observational study, not testing a specific intervention. It aims to enroll 600 participants to understand different types of musculoskeletal pain.
What's involved
Researchers will collect information on your childhood medical history, past treatments, when your pain started, and what your pain feels like now. They will also perform tests to see how your body senses pain and collect blood samples for immune system markers.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, which measure how your body senses pain, are taken at Baseline. The record does not specify any follow-up after this initial assessment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07602595

The BRIDGE Pain Study

Recruiting
Not specifiedAges 14–26Observational
Children's Hospital Medical Center, Cincinnati
~600 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Not applicable- observational study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Conditioned Pain Modulation (CPM) Profile (Pressure)
Measured over Baseline
+2 more outcomes measured
Juvenile Idiopathic Arthritis (JIA)
Fibromyalgia
Lupus
Scoliosis
Pectus Excavatum
Chronic Pain
Musculoskeletal Pain
1 sites across 1 states
Ohio1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Diagnosis of rheumatic/autoimmune disease/pain condition or surgery prior to age 18; Current age 14 to 26 years; Participant (and parent/legal guardian of participants \< 18 yo) can read and write in English; At least 1 year from diagnosis of pain or rheumatic disease; For individuals with MSK surgical history, at least 1 year after initial surgical intervention; For individuals with rheumatic disease, their disease must be considered inactive

Exclusion

They have active disease, or Other major medical comorbidities have developed after surgery following MSK surgical intervention.
  • Conditioned Pain Modulation (CPM) Profile (Pressure)Baseline

    CPM is defined by the change in pressure thresholds (increase) before and during cold immersion. Pressure thresholds will be measured using an algometer.

  • Conditioned Pain Modulation (CPM) Profile (Heat)Baseline

    CPM is defined by the change in heat pain intensity (decrease) before and during cold immersion. Heat stimuli will be delivered by a thermode and pain intensity measured by participant self report on the visual analog scale.

  • Temporal Summation (TS) ProfileBaseline

    TS is defined by the change in mechanical pain intensity (increase) after exposure to a series of pinprick stimuli. Pain intensity will be measured by participant self report on the visual analog scale.