This study is looking at whether certain hormone-blocking medications can help reverse inguinal hernias (a bulge in the groin area) in men aged 50 and older. Participants will receive either fulvestrant (an injection) or anastrozole (an oral pill) for six months. The main goal is to check the safety of these treatments. Researchers will also look at how well the treatments are tolerated, changes in hormone levels, hernia size, and how participants feel. To join, you must be a man at least 50 years old with a symptomatic, non-recurrent inguinal hernia confirmed by ultrasound. The study plans to enroll 30 participants, but its current status is unclear.

Study design

This is a Phase 1, single-center study that will randomly assign 30 men to one of three treatment groups. Participants will receive either fulvestrant (250 mg or 500 mg) or anastrozole (5 mg).

What's involved

You would receive injections of fulvestrant on specific days for the first month, then monthly for six months, or take anastrozole daily for six months. You would also have required visits and laboratory assessments.

Compensation

Not stated in the trial record.

Follow-up

Your safety will be measured at 6 months after starting treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.