A Study of ION775 for High Triglycerides

This study is testing a drug called ION775 to see how safe and effective it is for people with high triglycerides (hypertriglyceridemia) or very high triglycerides (severe hypertriglyceridemia). ION775 is given as a shot under the skin. To join, you must be an adult with fasting triglyceride levels of 350 mg/dL or higher, or 500 mg/dL or higher for severe cases. You should also be taking your usual medications for high cholesterol. The main goal is to see how much ION775 changes your fasting triglyceride levels after six months. The study is currently recruiting 72 participants, but its overall status is unclear.

Study design
This is an open-label study, meaning you and your doctors will know you are receiving ION775. It plans to enroll 72 participants.
What's involved
You would participate in a screening period lasting 4-6 weeks, followed by a 6-month treatment period.
Compensation
Not stated in the trial record.
Follow-up
After the 6-month treatment period, there is a 6-month follow-up period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07604974

A Study to Assess the Safety, Tolerability and Efficacy of ION775

Recruiting
PHASE2Ages 18+InterventionalTreatment
Ionis Pharmaceuticals, Inc.
~72 participants
Updated 2026-06-18 on ClinicalTrials.gov
What's tested:ION775

At a glance

Recruiting sites
16 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Change From Baseline in Fasting Triglyceride (TG)
Measured over Baseline, Month 6
Hypertriglyceridemia
Severe Hypertriglyceridemia
16 sites across 10 states
Texas5
Florida3
California1
Colorado1
Georgia1
Kentucky1
Michigan1
Ohio1

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  • Percent Change From Baseline in Fasting Triglyceride (TG)Baseline, Month 6