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The SEAS Study: Sensory Engagement and Activation During Noninvasive Stimulation

This study, called The SEAS Study, is looking for 40 healthy adults between 18 and 65 years old. It's testing how external electrical stimulation and ultrasound stimulation affect the brain. Researchers want to find measurable changes in brain activity (like electrical signals) after these stimulations. The study is currently unclear on its recruitment status. Success would mean finding clear physiological markers that show how the brain responds to these noninvasive stimulations.

Study design
This is an interventional study with a planned enrollment of 40 healthy adult participants. It's an early feasibility study, meaning it's an initial look at how these interventions work.
What's involved
You would participate in approximately 1-hour sessions with non-invasive recordings, and a study visit lasting about 3 hours.
Compensation
Not stated in the trial record.
Follow-up
Your brain activity will be measured at the start and after stimulation during the study visit, which lasts approximately 3 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07606573

The SEAS Study: Sensory Engagement and Activation During Noninvasive Stimulation

Recruiting
NAAges 18–65InterventionalBasic science
University of Minnesota
~40 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:External electrical stimulationUltrasound stimulation

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change From Baseline in HD-EEG Power Spectrum Magnitude After Active Versus Sham Stimulation
Measured over Baseline and post-stimulation assessment during the study visit, approximately 3 hours.

Conditions

Healthy Adult Participants

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Healthy Volunteers

NCT07606573

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • M Health Clinical Research Unit

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

  • M Health Clinics and Surgery Center and satellite Neurology Clinic locations

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

  • Translational Neurotechnology (TNT) Lab

    Minneapolis, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Rosana Esteller, Principal Investigator, PhD
[email protected]
612-624-1326
Email the study team

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Eligibility criteria

Inclusion

Able to provide written informed consent in English.
Willing and able to complete study procedures (e.g., \~1-hour sessions with non-invasive recordings, \~3-hour visit).

Exclusion

History of neurological disorders (e.g., epilepsy, migraines) or psychiatric conditions requiring medication.
Active implanted medical devices (e.g., pacemakers, cochlear implants) or metal in the neck/forearm that could interfere with stimulation or recordings.
Skin conditions or open wounds at stimulation sites (cervical neck, forearm).
Women who are pregnant or breastfeeding.
Current use of medications affecting autonomic or cortical function (e.g., beta-blockers, sedatives).
Inability to sit still for recordings or understand instructions (e.g., due to severe vision/hearing impairment).

What this trial measures

  • Change From Baseline in HD-EEG Power Spectrum Magnitude After Active Versus Sham StimulationBaseline and post-stimulation assessment during the study visit, approximately 3 hours.

    Change from baseline in power spectrum magnitude will be calculated from high-density electroencephalography recordings in standard EEG frequency bands. The primary comparison will be the within-participant difference in change from baseline between active stimulation and sham stimulation conditions.