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Blueberry Polyphenol Metabolism and Gut Microbiome Study

This study is looking at how your gut microbiome (the community of bacteria in your intestines) affects how your body processes blueberry polyphenols. You would drink a beverage made with 22 grams of freeze-dried blueberry powder. Researchers will then measure the levels of blueberry polyphenols in your blood over 24 hours to see how your body absorbs and uses them. The goal is to understand if differences in people's gut microbiomes lead to different ways their bodies handle these blueberry compounds. This study is for healthy adults aged 18 and older, and it aims to enroll about 125 participants.

Study design
This is an interventional, single-arm study that will include approximately 125 healthy adult participants.
What's involved
You would have a screening visit, an acute test day where you consume the blueberry beverage after an overnight fast, and a 24-hour follow-up visit.
Compensation
Participants will be compensated for their time.
Follow-up
You will be followed for 24 hours after consuming the blueberry beverage.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07607158

Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites

Recruiting
NAAges 18+Interventional
Colorado State University
~125 participants
Updated 2026-05-26 on ClinicalTrials.gov
What's tested:Freeze-dried blueberry powder beverage

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pharmacokinetics - Area under the curve (AUC) of circulating blueberry polyphenol metabolites
Measured over Baseline and 1, 2, 4, 6, 8 and 24 hours post-consumption
+2 more outcomes measured

Conditions

Microbiome Analysis
Metabolomics

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Healthy Volunteers

NCT07607158

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Colorado State University; Food and Nutrition Clinical Research Laboratory; Gifford Building Room 216; 502 West Lake Street, Fort Collins, CO 80523

    Fort Collins, Coloradostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Tiffany Weir, PhD
[email protected]
(970) 491-4631
Email the study team

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Eligibility criteria

Inclusion

Healthy adults ≥18 years of age
Able and willing to provide informed consent
Willing and able to adhere to all study procedures and visit requirements

Exclusion

Age \<18 years
Pregnant or breastfeeding
Presence of chronic diseases, including but not limited to cardiovascular disease, diabetes, cancer, kidney, liver, gastrointestinal, or pancreatic disease
Use of medications for chronic diseases that may interfere with study outcomes
Any condition known to negatively impact nutrient absorption (e.g., inflammatory bowel disease, celiac disease, gastroparesis)
Anemia (hemoglobin \<13.5 g/dL in men or \<12.0 g/dL in women)
Body mass index (BMI) ≤18.5 kg/m²
Use of antibiotics within the past 2 months
Recent blood draw within 1 week prior to study participation
Currently participating in another research study involving a diet or exercise intervention
Known allergy or contraindication to blueberry products or study procedures
Unwilling or unable to comply with study requirements

What this trial measures

  • Pharmacokinetics - Area under the curve (AUC) of circulating blueberry polyphenol metabolitesBaseline and 1, 2, 4, 6, 8 and 24 hours post-consumption

    Pharmacokinetics - Area under the curve (AUC) will be calculated from plasma concentrations of blueberry-derived polyphenol metabolites, measured at serial time points following a single-dose blueberry intervention.

  • Pharmacokinetics - Maximum concentration (Cmax) of circulating blueberry polyphenol metabolitesBaseline and 1, 2, 4, 6, 8 and 24 hours post-consumption

    Pharmacokinetics - Maximum concentration (Cmax) will be calculated from plasma concentrations of blueberry-derived polyphenol metabolites, measured at serial time points following a single-dose blueberry intervention.

  • Pharmacokinetics - Time to maximum concentration (Tmax) of circulating blueberry polyphenol metabolitesBaseline and 1, 2, 4, 6, 8 and 24 hours post-consumption

    Pharmacokinetics - Time to maximum concentration (Tmax) will be calculated from plasma concentrations of blueberry-derived polyphenol metabolites, measured at serial time points following a single-dose blueberry intervention.