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Study on rTMS for Post-Stroke Aphasia

This study is looking at ways to help people recover their language skills (aphasia) after a stroke. It tests two types of repetitive Transcranial Magnetic Stimulation (rTMS) – continuous Theta Burst Stimulation and intermittent Theta Burst Stimulation – which use a device to stimulate specific parts of the brain. Some participants will also receive a sham (inactive) stimulation. All participants will also get Semantic Feature Analysis, a type of speech therapy. Researchers want to see if stimulating the left or right anterior temporal lobe can improve your ability to name pictures. You might be able to join if you are right-handed, a native English speaker, had a single stroke on the left side of your brain, and have been diagnosed with aphasia. The study aims to enroll 45 participants.

Study design
This is an interventional study with an unclear status, planning to enroll 45 participants. It compares two types of active brain stimulation and a sham stimulation, along with behavioral therapy.
What's involved
You will have a baseline assessment within 7 days before the intervention, a post-intervention assessment within 3 days after the final session, and a follow-up assessment 1 month later. You will also receive 30 minutes of Semantic Feature Analysis therapy.
Compensation
Not stated in the trial record.
Follow-up
Participants will have a follow-up assessment conducted 1 month after the end of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07608588

Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

Recruiting
NAAges 18+InterventionalTreatment
University of South Carolina
~45 participants
Updated 2026-05-29 on ClinicalTrials.gov
What's tested:continuous Theta Burst Stimulationintermittent Theta Burst StimulationTranscranial Magnetic Stimulation ShamSemantic Feature Analysis

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Picture Naming task accuracy
Measured over Baseline assessment conducted within 7 days prior to intervention Post-intervention assessment conducted within 3 days after the final intervention session Follow-up assessment conducted 1 month after the end of the intervention

Conditions

Stroke
Aphasia

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NCT07608588

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • McCausland Center

    Columbia, South Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Sophie Arheix-Parras, PhD
[email protected]
803-467-8018
Email the study team

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Eligibility criteria

Inclusion

Right-handedness (assesed using the Edinburgh Handedness Inventory)
Native English speakers
Single left hemispheric stroke
Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician

Exclusion

Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)
Major phonological impairments (defined as \> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)
Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)
Contraindication to MRI
Stroke involving the left ATL
Severe depression or psychiatric history
Illiteracy
Known neurodegenerative disorders
Severe uncorrected visual or hearing impairments

What this trial measures

  • Picture Naming task accuracyBaseline assessment conducted within 7 days prior to intervention Post-intervention assessment conducted within 3 days after the final intervention session Follow-up assessment conducted 1 month after the end of the intervention

    The primary outcome is improvement in accuracy of the a Picture Naming task. Participants will complete a Picture Naming tasks based on the Older Adult Naming Test. Participants will name items from pictures as quickly and accurately as possible. Items will include mid-frequency words and 10 pictures of middle-to-late age-of-acquisition words (mean = 10.01 years, SD = 1.16).