This study aims to understand how deep cleaning (non-surgical periodontal therapy) affects the body's genetic switches (epigenetic modifications) in obese individuals with gum disease (periodontitis). Researchers will compare changes in these genetic switches, inflammation markers, and mouth bacteria in people with periodontitis who are obese versus those who are not obese. The study will look at these changes before and after deep cleaning. You may be able to join if you are an adult aged 18 to 75, have periodontitis, and have not had recent gum treatment or used tobacco. The goal is to see if deep cleaning leads to long-term changes in these genetic switches in obese individuals with gum disease.

Study design

This interventional study plans to enroll 40 participants, divided into two groups: obese with periodontitis and non-obese with periodontitis. The study will evaluate changes both at the start and after treatment.

What's involved

Participants will receive non-surgical periodontal therapy (deep cleaning). Measurements of host-specific epigenetic signatures, inflammatory cytokine profiles, and periodontal microbial composition will be taken at the beginning of the study (Baseline/Day 1).

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints are measured at Baseline/Day 1, but the study aims to monitor longitudinal changes, suggesting follow-up beyond this initial measurement. The exact duration is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.