aPBI Re-irradiation for Recurrent Breast Cancer

This study is looking at a type of radiation therapy called aPBI (Accelerated Partial Breast Irradiation) for women who have had breast cancer return in the same breast after previous radiation. The aPBI treatment involves 30 Gy (Gray, a unit of radiation dose) given in 5 sessions using a VMAT (Volumetric Modulated Arc Therapy) technique. The main goal is to see if this re-irradiation treatment causes an acceptably low level of side effects within one year. Researchers also want to see how well it controls the cancer locally and to look at cosmetic results. You may be able to join if you are 40 or older, have a second breast cancer in the same breast diagnosed more than a year after your first treatment, have had prior radiation, and still have your breast. The study is currently unclear on its recruitment status and plans to enroll 30 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 30 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Treatment-associated toxicity will be measured within one year after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07612254

aPBI Re-irradiation

Not Yet Recruiting
PHASE1Ages 40+InterventionalTreatment
Dartmouth-Hitchcock Medical Center
~30 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:Reirradiation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Treatment-associated toxicity
Measured over Within 1 year
Breast Cancer Recurrent
1 sites across 1 states
New Hampshire1

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Grade 1-2 disease
ER-positive histology
Tumor size up to 2 cm
Patient's age 40 or older 5. Patients who will undergo breast radiation therapy at D-H Lebanon, D-H St. Johnsbury, or Cheshire Medical Center. 6. Patients must have a lumpectomy cavity that can be delineated on CT scan. 7. Patients who are able to provide informed consent. 8. Females of childbearing potential must have a negative urine or serum pregnancy test within 14 days of study entry. 9. Females of childbearing potential must not be pregnant and not lactating and willing to use medically acceptable form of contraception during radiation therapy.
  • Treatment-associated toxicityWithin 1 year

    Acceptably low acute treatment-associated adverse events following breast re-irradiation with aPBI.