This study is looking at how stress-modulating proteins in the brain interact with alcohol use disorder (AUD). Researchers will use special imaging scans called PET scans with a radiotracer called [C-11]NOP-1A, along with a medication called hydrocortisone, to see how these proteins respond to stress. They want to understand if these responses are different in people with AUD who drink heavily compared to healthy individuals, and if these differences might predict a return to drinking. The study aims to enroll 90 participants and is currently unclear about its recruitment status. To be eligible, you must be between 18 and 55 years old, meet criteria for moderate or severe AUD, and engage in heavy drinking.

Study design

This interventional study plans to enroll 90 participants to compare brain responses in individuals with heavy drinking alcohol use disorder and healthy controls.

What's involved

You will receive a baseline [C-11]NOP-1A PET scan, an intravenous dose of hydrocortisone, and then another [C-11]NOP-1A PET scan. You will also have an 8-week follow-up period.

Compensation

Not stated in the trial record.

Follow-up

Your progress will be followed for 8 weeks after the initial procedures to track negative ETG tests (a measure of alcohol use).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.