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Understanding Recovery After Coma and Disorders of Consciousness

This observational study aims to better understand how people recover after experiencing a coma or disorders of consciousness due to serious brain injuries or illnesses like stroke, cardiac arrest, or traumatic brain injury. Researchers will collect information from your medical records during your hospital stay, including details about your illness, treatments, brain scans, and neurologic exams. The goal is to learn which medical, psychological, and social factors are linked to recovery over time. You may be eligible if you are 18 years or older and have been in a coma for at least 24 hours, or passed away before 24 hours without regaining consciousness. The study is not testing any specific treatments but rather observing recovery.

Study design
This is an observational study aiming to enroll 2000 participants. It is not testing a new drug or intervention.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your recovery will be assessed at various time points, starting at 1 month and continuing every 6 months after coma onset until the study ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07614074

Recovery Trajectory for Coma and Disorders of Consciousness

Recruiting
Not specifiedAges 18+Observational
University of California, San Francisco
~2,000 participants
Updated 2026-06-02 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Modified Rankin Scale (mRS)
Measured over 1, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, and 48 months after coma onset, with continued assessments at 6-month intervals thereafter until study completion

Conditions

Coma
Disorders of Consciousness
Cardiac Arrest (CA)
Traumatic Brain Injuries
Ischemic Stroke
Hemorrhagic Stroke, Intracerebral
Meningitis/Encephalitis
Status Epilepticus

Explore related trials

Cardiac ArrestComaConsciousness DisordersEncephalitisHemorrhagic StrokeIschemic StrokeMeningitisStatus EpilepticusTraumatic Encephalopathy

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Claude Hemphill, MD, MAS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Claude Hemphill, MD, MAS
[email protected]
415-476-5100
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age greater than or equal to 18 years on the day of hospital admission
Coma duration of at least 24 hours from presentation to the receiving hospital, or died prior to the 24 hour timepoint without return of consciousness. Coma defined as: GCS score of less than or equal to 10 AND GCS score of less than 6 on the motor component of the GCS(not following commands) AND GCS score less than 3 on the verbal component AND alteration of consciousness not explained by sedation only
Coma due to a neurological process (Including but not limited to: trauma, stroke, hypoxic- ischemic brain injury (HIBI), CNS infection, seizure, other processes at the discretion of the investigator)
Admission to the intensive care unit, or deceased prior to admission.

Exclusion

Pre-existing score of 5 or less on the motor component of the Glasgow Coma Scale prior to hospital admission.
Transfer from another acute care hospital in which the motor component of the Glasgow Coma Scale on the day after initial hospital arrival is not known or cannot be reconstructed from medical records or history.
Coma due to sepsis, systemic metabolic processes (ex: organ failure or sedation).
GCS score of greater than 2 for eye opening with lack of command following due to a focal brain lesion causing receptive aphasia.
Prisoner

What this trial measures

  • Modified Rankin Scale (mRS)1, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, and 48 months after coma onset, with continued assessments at 6-month intervals thereafter until study completion

    Functional outcome will be assessed using the modified Rankin Scale, a clinician-administered measure of global disability following neurologic injury. Scores range from 0 to 6, with higher scores indicating greater disability.