Study of EVO756 for Migraine

This study is testing a new medication called EVO756 to see if it can reduce the number of monthly migraine days in adults. Researchers will compare two different doses of EVO756 to a placebo (an inactive substance) over a 12-week treatment period. You might be able to join if you are between 18 and 64 years old, have migraines with or without aura, and have tried other migraine prevention treatments that didn't work. You cannot join if you have trouble telling your migraines apart from other headaches or are using certain medications. The study is looking for 330 participants, but its current recruitment status is unclear.

Study design
This interventional study will involve 330 participants who will receive either EVO756 (two different doses) or a placebo daily.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at the last month of the 12-week treatment period, but further follow-up is not specified.

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NCT07616128

Study of EVO756 in Adults With Migraine

Recruiting
PHASE2Ages 18–64InterventionalPrevention
Evommune, Inc.
~330 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:EVO756, Dose 1EVO756, Dose 2Placebo

At a glance

Recruiting sites
19 of 20 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean change from baseline in the number of monthly migraine days (MMD)
Measured over Last month of the 12-week treatment period
Migraine
20 sites across 12 states
Florida4
California3
Texas3
North Carolina2
Arizona1
Connecticut1
Georgia1
Michigan1

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Eligibility criteria

Inclusion

Adults aged 18 to \<65 years
Migraine with or without aura, per ICHD-3 criteria
History of failure with prior preventive migraine treatments
Not currently using migraine preventive therapy

Exclusion

Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders
Use of certain medications
Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities
  • Mean change from baseline in the number of monthly migraine days (MMD)Last month of the 12-week treatment period