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NCT07618364

The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease

Recruiting
NAAges 18+InterventionalTreatment
Rinsada
~33 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:Rinsada

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MMP-9 Positivity
Measured over 3 Hours

Conditions

Dry Eye Syndromes
Dry Eye
Ocular Surface Disease

Explore related trials

Dry Eye SyndromeMMP9 Gene

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Srinivas S Kondapalli
[email protected]
4123243010
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Eligibility criteria

Inclusion

MMP-9 Positivity in both eyes

Exclusion

Active ocular infection, including bacterial, viral, or fungal conjunctivitis Acute allergic conjunctivitis or severe seasonal ocular allergy flare History of autoimmune ocular surface disease (e.g., Sjögren syndrome, ocular cicatricial pemphigoid, Stevens-Johnson syndrome) Current use of topical anti-inflammatory medications, including corticosteroids, cyclosporine, lifitegrast, or topical NSAIDs within 14-30 days prior to enrollment Initiation of new ocular or systemic anti-inflammatory therapy during the study period Contact lens wear within 12-24 hours prior to testing Ocular surgery or laser procedures within the previous 3-6 months Current punctal plug use or punctal occlusion procedures within the prior 3 months Severe aqueous-deficient dry eye preventing adequate tear sample acquisition or reliable InflammaDry testing Use of preserved artificial tears within a specified washout period Eyelid abnormalities or active blepharitis requiring treatment Pregnancy or breastfeeding (optional depending on IRB requirements) History of hypersensitivity to saline irrigation or study materials Any systemic inflammatory disease judged by investigators to confound tear film MMP-9 level

What this trial measures

  • MMP-9 Positivity3 Hours

    Tear MMP-9 levels will be assessed using a point-of-care diagnostic assay. Change from baseline to the specified follow-up visit will be analyzed.