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Dorsal Root Ganglion Stimulation for Lower Motor Neuron Damage

This study is looking at how temporarily using the Abbott Dorsal Root Ganglion Neurostimulator, a device that sends electrical signals to nerves in your spine, affects people with spinal cord injuries and lower motor neuron damage. Researchers want to see if this stimulation, combined with rehabilitation exercises over 10 days, can improve muscle activity and function. To join, you need to be between 18 and 70 years old, have a spinal cord injury below the tenth thoracic vertebra (part of your upper back), and have some intact reflexes below your injury. The main goal is to see if your ASIA Impairment Scale (a way to measure spinal cord injury severity) category changes after 14 days. This study is currently unclear on its recruitment status and plans to enroll one participant.

Study design
This is an interventional study with one planned participant. The phase of the study is not specified.
What's involved
You would have leads temporarily implanted into your lower spine for the Abbott Dorsal Root Ganglion Neurostimulator. You would then undergo 2-3 hour rehabilitation sessions with electrical stimulation over 10 days.
Compensation
Not stated in the trial record.
Follow-up
Your ASIA Impairment Scale will be measured at baseline and again at 14 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07619300

Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage

Not Yet Recruiting
NAAges 18–70InterventionalBasic science
Peter J. Grahn, Ph.D.
~1 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Abbot Dorsal Root Ganglion Neurostimulator

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change America Spinal Injury Association (ASIA) Impairment Scale categorization
Measured over Baseline, 14 days

Conditions

Spinal Cord Injuries
Lower Motor Neuron Disease

Explore related trials

Lower motor neuron diseaseSpinal Cord Injury

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Peter J. Grahn, Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Peter J. Grahn, Ph.D.
[email protected]
507-316-5556
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Traumatic and non-traumatic spinal cord injury (SCI)
ASIA Impairment Scale (AIS) A-D
SCI below the tenth thoracic vertebral level
Greater than 1 year post-SCI
Intact spinal reflexes at or below injury level in 1 or more muscles

Exclusion

Currently a prison inmate, or awaiting trial, related to criminal activity
Pregnancy at the time of screening for trial enrollment
Active, untreated urinary tract infection
Unhealed decubitus ulcer
Unhealed skeletal fracture
Spinal abnormality that may impede percutaneous implantation of spinal electrodes
Untreated clinical diagnosis of psychiatric disorder
Joint contractures that impede typical range of motion
Non-MRI-compatible implanted medical devices
Other implanted stimulation devices (e.g., deep brain stimulator, cardiac pacemaker, diaphragmatic pacer, etc.)
Active participation in an interventional clinical trial which, based on the research team's assessment, may compromise protocol compliance, safety, and/or validity of data collected during this study
History of clinically diagnosed cardiopulmonary disorder, such as severe orthostatic hypotension, which may impede participation in rehabilitation activities such as changes in body position such as supine-to-sit-to-stand activities, prolonged standing, or stepping
History of frequent and/or severe autonomic dysreflexia
History of seizure disorder
Any illness or condition which, based on the research team's assessment, will compromise with the patient's ability to comply with the protocol, patient safety, or the validity of the data collected during this study

What this trial measures

  • Change America Spinal Injury Association (ASIA) Impairment Scale categorizationBaseline, 14 days

    The America Spinal Injury Association Impairment Scale is a provider assessment that categorizes spinal cord injuries into five distinct classifications, each representing different degrees of neurological impairment and functional preservation. Categories are defined as Grade A: complete impairment; Grade B: sensory but not motor function preserved; Grade C: motor function incomplete (most muscles): Grade D: motor function incomplete (half of key muscles); and Grade E: normal sensory and motor functions.