Lean Beef and Brain Health Study
This study is looking at whether eating lean beef every day can help support brain health as people get older. Researchers will provide participants with either 5.5 ounces (156 grams) of cooked lean beef daily or a non-beef control (cottage cheese and whey protein) for two separate 14-day periods. They want to see how these diets affect important markers in your blood related to brain health, specifically changes in p-tau217 and the Aβ42/40 ratio, which are linked to cognitive function. This study is for generally healthy adults aged 65 and older who are willing to eat the provided foods. The goal is to understand the direct biological effects of a beef-rich diet on brain health.
- Study design
- This interventional study plans to enroll 20 generally healthy older adults. Participants will complete two separate 2-week dietary phases, one with lean beef and one with a non-beef control.
- What's involved
- You would consume either 5.5 ounces of lean beef or a non-beef control daily for two separate 14-day periods. You would also maintain your usual diet, activity, and weight.
- Compensation
- Not stated in the trial record.
- Follow-up
- Blood markers will be measured at the beginning and end of each 14-day dietary phase.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Change in Plasma Phosphorylated Tau-217 (p-tau217) ConcentrationBaseline (Day 0) and End of Intervention (Day 14) for each of the two dietary phases.
Quantitative change in fasting plasma concentrations of p-tau217, a blood-based biomarker indicative of neurodegeneration and cognitive decline. This will be measured using commercially available Enzyme-Linked Immunosorbent Assays
- Change in Plasma Amyloid-Beta 42/40 (Aβ42/40) RatioBaseline (Day 0) and End of Intervention (Day 14) for each of the two dietary phases.
Quantitative change in the ratio of fasting plasma Aβ42 to Aβ40, a recognized biomarker for early amyloid pathology. This will be measured using commercially available ELISA kits.