Food and Metabolism Study for Prediabetes and Insulin Resistance

This study is looking at how eating avocados regularly affects triglyceride (a type of fat in your blood) and glucose (sugar) levels in people with prediabetes and insulin resistance (when your body doesn't use insulin effectively). You could be eligible if you are 40-70 years old and have high triglycerides (above 115 mg/dL) and insulin resistance (HOMA-IR >2.5). Participants will follow either an avocado meal plan or a control meal plan for 4 weeks. The main goal is to see changes in your triglyceride levels after 4 weeks. The study is currently unclear on its recruitment status and plans to enroll 82 people.

Study design: This is a randomized, 2-arm study with 82 participants. It compares an avocado meal plan to a control meal plan.
What's involved: You will have a screening visit including general measurements, a finger prick for blood sugar, and a blood draw. You will need to eat all meals and snacks provided by the study for 4 weeks.
Compensation: Not stated in the trial record.
Follow-up: Your triglyceride levels will be measured at baseline and again after 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Food and Metabolism Study

Recruiting

NAAges 40–70InterventionalPrevention

Clinical Nutrition Research Center, Illinois Institute of Technology

~82 participants

Updated 2026-07-01 on ClinicalTrials.gov

What's tested:Avocado meal planControl meal plan

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Changes in serum biomarker: triglycerides

Measured over baseline and 4 weeks

Conditions

Prediabetes

Insulin Resistance

Triglycerides

Lipids Metabolism

Where it's being run

1 sites across 1 states

Illinois1

Study leadership

Britt Burton-Freeman, PhD · PRINCIPAL_INVESTIGATOR · Food Sci and Nut Programs

Who to contact

Chelsea Preiss, MS

[email protected]

312-567-5300

Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Men or women, 40-70 years of age.

Fasting triglycerides (TG) \>115 mg/dL.

Insulin resistance as measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) \>2.5.

Able to provide informed consent.

Able to comply with and perform the procedures requested by the protocol, specifically eat all the meals and snacks provided by the study which will be almost all your food (\~ 80% of calories per day).

Able to come to the clinic up to 6 times during the study.

Able to maintain usual physical activity pattern.

Able to avoid/abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit.

Exclusion

Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions.

Fasting blood sugar ≥125 mg/dL. Men and women with blood pressure \>160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit.

Men and women with history of diabetes cardiovascular events, respiratory, renal, gastrointestinal, hepatic or eye disease or surgery- within a year.

Men and women who have or had cancer other than non-melanoma skin cancer in the past 5 years.

Men and women taking over the counter or prescription medications or dietary supplements that may interfere with study procedures or endpoints.

Men and women who are on a specialized diet (vegan, vegetarian, keto, etc.). - - Men and women who consume nuts or peanuts daily or most days of the week.

Men and women who are not weight stable (+/-10lbs in previous 2 months). Men and women who have excessive use of drugs or alcohol (ie., addictions) within the past 2 years.

Men and women with documented physical or mental disease/condition, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.

Women who are known to be pregnant or who are intending to become pregnant over the course of the study.

Women who are lactating.

Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI. Has used antibiotics within the previous 2 months.

History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional.

Excessive coffee and tea consumers (\> 4 cups/d).

Donated blood within the last 3 months.

Women who are taking an unstable dose and brand of hormonal contraceptives and/or a stable dose and brand for less than 6 months.

Unusual working hours (working overnight).

What this trial measures

Changes in serum biomarker: triglyceridesbaseline and 4 weeks
analyzed by McLendon labs

Trialytics