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NCT07625956

Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for Smoking

Enrolling by Invitation
PHASE4Ages 21+InterventionalTreatment
Medical University of South Carolina
~10 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Nicotine replacement therapy patchesOral nicotine pouches

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility
Measured over Days 1-56
+1 more outcome measured

Conditions

Smoking ( Cigarette)

Explore related trials

Smoking

Where it's being run

1 sites across 1 states
South Carolina1

Study leadership

  • Amanda Palmer, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 21 years or older
Currently enrolled in and completed the Pack2Pouch parent study
Current combustible tobacco smoking at extension study enrollment
Able to attend in-person visits in the Charleston, SC area
Access to internet and mobile communication

Exclusion

Pregnancy, breastfeeding, or nursing
Medical contraindications to nicotine replacement therapy
Current use of smoking cessation medications
Non-English proficiency
Use of other combustible tobacco or frequent non-combustible nicotine products outside study protocol

What this trial measures

  • FeasibilityDays 1-56

    Feasibility endpoints include 1) the proportion of eligible subjects who subsequently enroll; 2) the proportion of enrolled subjects who complete the Day 28 and Day 56 assessments; and 3) the proportion of enrolled subjects who complete ≥80% of their daily surveys during the switching period.

  • AcceptabilityDay 28

    Acceptability endpoints will be measured by the Acceptability of Intervention Measure (AIM). This measure includes 4 items rated on scale of 1 to 5. Scores are created by averaging responses, with values ranging from 1 to 5. Higher values indicate higher acceptability.