Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

This study is looking at the safety and whether it's possible to perform a procedure called corneal cross-linking on both eyes on the same day for people with keratoconus. Keratoconus is an eye condition that causes the cornea (the clear front part of your eye) to thin and bulge. The procedure uses Riboflavin Ophthalmic Solutions (eye drops) and a UV-A Irradiation System (a special light) to strengthen the cornea. The main goal is to see if this same-day treatment can be successfully completed in both eyes. You may be able to join if you are 13 years or older, have keratoconus in both eyes, and can follow study instructions. We are looking to enroll 15 participants, but the current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 15 participants.
What's involved
You would need to provide written informed consent and be willing and able to comply with study instructions and follow-up visits.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at approximately 2.5 months, indicating follow-up for at least that duration.

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NCT07629557

Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

Recruiting
PHASE4Ages 13+InterventionalTreatment
Glaukos Corporation
~15 participants
Updated 2026-06-05 on ClinicalTrials.gov
What's tested:Riboflavin Ophthalmic SolutionsUV-A Irradiation System

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Successful completion of bilateral epithelium-on corneal collagen cross-linking.
Measured over Approximately 2.5 Months
Keratoconus
1 sites across 1 states
Ohio1
  • Study Director · STUDY_DIRECTOR · Glaukos Corporation

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Eligibility criteria

Inclusion

Provide written informed consent
Willing and able to comply with study instructions and follow-up visits
Diagnosis of keratoconus in each eye

Exclusion

Known allergy or sensitivity to study medications
History of corneal disease
Prior corneal cross-linking in either eye
Pregnant, nursing, or planning pregnancy during the study period
Participated in other investigational drug or device trial within 30 days of the study
  • Successful completion of bilateral epithelium-on corneal collagen cross-linking.Approximately 2.5 Months

    Portion of subjects that the Investigator completed bilateral epithelium-on corneal collagen cross-linking treatment on the same day.