Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

Not Yet Recruiting

PHASE2Ages 18+InterventionalTreatment

Matthew Spector

~40 participants

Updated 2026-07-31 on ClinicalTrials.gov

What's tested:Bevonescein (ALM 488) Infusion

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Change in Voice Handicap Index (VHI) scores

Measured over At baseline (before surgery) and at 28 days post-surgery

Head and Neck Disorder

Head and Neck Cancer

1 sites across 1 states

Pennsylvania1

Jennifer Ruth

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Change in Voice Handicap Index (VHI) scoresAt baseline (before surgery) and at 28 days post-surgery
Mean change in Voice Handicap Index (VHI) scores pre-operatively and post-operatively. Voice Handicap Index (VHI) is a 30-item self-administered questionnaire divided equally into three subscales designed to measure a patient's perceived handicap related to their voice disorder across functional, physical, and emotional domains. Functional (F) subscale (10 items) evaluates how voice problems affect daily activities, work, and social interactions (difficulty being understood on the phone or professional duty limitations). Physical (P) subscale (10 items) addresses physical sensations or characteristics of the voice problem (vocal fatigue, strain, or pitch changes). Emotional (E) subscale (10 items) assesses the emotional impact of a voice disorder (frustration, embarrassment, or anxiety) related to voice use. Item scores range from 0 (never) to 4 (always), with higher scores indicating a greater perceived handicap. Total VHI score: 0 to 120