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NCT07635017

Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation

Not Yet Recruiting
NAAges 18–40InterventionalBasic science
Carnegie Mellon University
~25 participants
Updated 2026-06-09 on ClinicalTrials.gov
What's tested:Transcranial Electrical StimulationTranscranial Magnetic StimulationTES + TMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor Evoked Potential Amplitude Change
Measured over MEP recorded at the same time as the diagnostic TMS pre-intervention and post-intervention of the 2,000 pulse stimulation at every session for at most 8 months / 24 sessions. Delta/change assessed after each session.

Conditions

Cortical Excitability
Healthy
TMS
Menstrual Cycle
Menopause

Explore related trials

Healthy Subjects

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Pulkit Grover
[email protected]
412-268-3644
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Eligibility criteria

Inclusion

Age between 18 and 40 years old
Female subjects must have regular menstrual cycles (defined as a cycle that occurs at predictable intervals, typically between 24 and 38-days length) via self-report

Exclusion

Allergies to henna
Allergies to gel used for electrodes
History of seizures or epilepsy
Subjects must not have any serious disease, disorder, infection, or cognitive impairments that could affect their ability to participate in this study.
Female subjects of child-bearing potential must not be pregnant
Subjects must not have any implanted stimulators or pulse generators
Subjects must not have heart disease, including known arrhythmia
Subjects must not have any metal implants in their head

What this trial measures

  • Motor Evoked Potential Amplitude ChangeMEP recorded at the same time as the diagnostic TMS pre-intervention and post-intervention of the 2,000 pulse stimulation at every session for at most 8 months / 24 sessions. Delta/change assessed after each session.

    Motor evoked potential (MEP) amplitude is recorded via surface EMG electrodes placed on the upper or lower limb musculature in response to single-pulse diagnostic TMS delivered to the primary motor cortex (M1). MEP amplitude is measured as the peak-to-peak voltage of the evoked muscle response in millivolts. The primary outcome is the change in trial-averaged MEP amplitude from before to after a train of up to 2,000 pulses of TMS, TES, or combined TMS+TES. This delta is compared across two hormonal phases of the menstrual cycle - estrogen nadir (days 1-3) and the late follicular phase (days 10-14) - and across the three intervention arms. A larger positive delta indicates greater corticospinal excitability / synpatic potentiation following stimulation, while a negative delta indicates suppression of corticospinal excitability / synpatic potentiation.