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NCT07635940

Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture

Not Yet Recruiting
NAAges 18–60InterventionalTreatment
University of Colorado, Denver
~60 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:continuous theta burst stimulation (cTBS)Intermittent theta burst stimulation (iTBS)Sham

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Social Cognition Task Battery Performance
Measured over within 10 minutes after the intervention.
+1 more outcome measured

Conditions

Psychopathy

Explore related trials

Antisocial Personality Disorder

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

Drew E Winters, PhD.
[email protected]
303-724-1000
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Eligibility criteria

Inclusion

18-60 years.
Elevated psychopathy as defined by the self-report psychopathy scale.
IQ \>= 80.
No prior diagnosis or current risk of Autism as defined by the autism spectrum quotient.
Negative urine drug screen.
At least 7 Days of abstinence from substance use (excluding nicotine)
Able to provide informed consent.
No change in psychiatric medication regimen, or medication-free, for 4 weeks before study.
Adequate English proficiency to complete study procedures and assessments.

Exclusion

Current or lifetime DSM-5 psychotic disorder, schizophrenia, schizoaffective disorder, bipolar disorder, or autism spectrum disorder.
IQ \< 80.
Clinically significant neurological disorder or medical illness that would make study participation unsafe, including a history of seizures or significant cardiovascular disease.
Clinically significant abnormality identified on baseline MRI.
Contraindication to MRI or inability to undergo MRI scanning.
Current pregnancy or breastfeeding.
History of head injury resulting in loss of consciousness greater than 15 minutes.
Diagnosis of dementia.
Current prescription for benzodiazepines or anticonvulsants.
Metal implants or non-removable metal objects above the waist.
Lifetime history of prior clinical treatment with transcranial magnetic stimulation (TMS).
Serious risk of suicide or homicide.
Unable or unwilling to comply with study procedures.
History of intractable migraine.
Claustrophobia or inability to tolerate enclosed spaces required for MRI procedures.

What this trial measures

  • Social Cognition Task Battery Performancewithin 10 minutes after the intervention.

    Performance on a social cognition task battery assessing facial emotion recognition (Emotion Recognition Task), perspective taking (Visual Perspective Taking Task), theory of mind (Movie Assessment of Social Cognition Task), and social decision-making (Altruistic/Antisocial game). Accuracy and reaction time will be analyzed using mixed-effects models to compare active stimulation versus sham stimulation across tasks. Higher accuracy values indicate better performance, whereas lower reaction times indicate better performance.

  • Serial and Parallel Cognitive Processing Task Performancewithin 10 minutes after the intervention.

    Performance on the Miller serial/parallel cognitive processing task. Trial-level accuracy and/or reaction time will be analyzed using mixed-effects models to compare active stimulation versus sham stimulation across serial and parallel processing conditions.