NCT07641504
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
Not Yet Recruiting
PHASE2Ages 18+InterventionalTreatmentEli Lilly and Company
~150 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:LY4065967Placebo
At a glance
Recruiting sites
0 of 37 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS)
Measured over Baseline, Week 8
Conditions
Where it's being run
37 sites across 19 statesFlorida12
California3
Arizona2
Massachusetts2
Missouri2
Texas2
Washington2
Alabama1
Study leadership
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Who to contact
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
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Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Have a history of low back pain for at least 3 months located between the 12th thoracic vertebra and the lower gluteal folds, with or without radiation
Have a body mass index at screening of ≤40 kilograms per meter squared (kg/m²).
Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening
Exclusion
Are pregnant or breastfeeding
Have used a therapeutic injection to the spine in the 3 months prior to screening
Are using a spinal cord stimulator or dorsal root ganglion stimulator
Have ongoing complex regional pain syndrome or other concurrent medical conditions that could interfere with the evaluation of CLBP
Have a history of major spinal deformity, such as spondylolisthesis, spondylolysis, scoliosis, or spina bifida, that causes instability to the spine
Have an abnormal blood pressure (BP) systolic BP is greater than 140 millimeters mercury (\>140 mm Hg) and diastolic BP\>90 mm Hg at screening • Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator
What this trial measures
- Change from Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS)Baseline, Week 8