NCT07643493
CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance
Not Yet Recruiting
PHASE4Ages 18–99InterventionalTreatmentDavid DornbosInvestigator-initiated
~80 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:Tissue Plasminogen Activator (tPA)Isotonic solution
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assess the Impact of Continuous Tissue Plasminogen Activator (TPA) Infusion on the Speed of Intraventricular Hemorrhage (IVH) Clearance
Measured over Enrollment through 90 days
+1 more outcome measured
Conditions
Where it's being run
1 sites across 1 statesKentucky1
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Male or female, age 18 years and older
Intraventricular hemorrhage requiring EVD placement for treatment as determined by the cerebrovascular neurosurgical faculty member caring for the patient as per standard of care
Baseline mRS 0 or 1
Consenting requirements met as outlined below
Exclusion
IVH of traumatic origin
Inability to initiate treatment within 24 hours of presentation
Incarcerated individuals, pregnant individuals, or other conditions as deemed by the investigator to potentially confound study data
Presence of evidence of severe brainstem dysfunction on presentation (absence of brain stem reflexes, fixed/dilated pupils)
What this trial measures
- Assess the Impact of Continuous Tissue Plasminogen Activator (TPA) Infusion on the Speed of Intraventricular Hemorrhage (IVH) ClearanceEnrollment through 90 days
Assess through measurement of blood volume seen on imaging in the form of daily Head CT or Head MRI
- Assess the Impact of Continuous Tissue Plasminogen Activator (TPA) Infusion on Ventricular Catheter LiberalizationEnrollment through 90 days
Record duration of time catheter is in place. Timepoints will be recorded from the medical record.