NCT07646873
PET-Enabled Dual-Energy CT in Multiple Myeloma
Not Yet Recruiting
NAAges 18+InterventionalDiagnosticUniversity of California, DavisInvestigator-initiated
~45 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:PET-enabled dual-energy CT imagingX-ray dual-energy CT imaging
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Agreement between PET-enabled DECT and X-ray DECT measurements of bone marrow tissue fractions
Measured over Baseline imaging visit; and for multiple myeloma participants, follow-up imaging at approximately Day +90 after CAR T-cell therapy initiation
Conditions
Where it's being run
1 sites across 1 statesCalifornia1
Study leadership
- Guobao Wang, PhD · PRINCIPAL_INVESTIGATOR · University of California, Davis
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Adults (age ≥ 18 years old)
Ability to understand and willingness to sign an informed consent form
Ability to adhere to the study visit schedule and other protocol requirements.
Willing and able to fast for at least 6 hours before and for the duration of the scan
No strenuous exercise for 24 hours prior to being scanned
Willing to lie on the scanner bed for up to 60 minutes
Patients with multiple myeloma who are planned to receive CAR T-cell therapy with any FDA-approved product, including Idecel and Ciltacel. Patients with prior chemo-immunotherapy are permitted.
Able to undergo bone marrow aspirate/biopsy procedure
Exclusion
Self-reported history of dysphoria or anxiety in closed spaces
Body weight \>240 kg due to limitations of the scanner bed
Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy or bilateral ovarian removal is available)
Blood glucose greater than 200 as assessed by fingerstick method before injection of 18F-FDG
Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only. That is, PET scans are not performed as part of a patient's treatment plan (e.g. standard of care, therapeutic purposes, or clinical care) and the research study did not intend to provide therapeutic benefit to the patient.
Prisoners
Any condition that would prevent the understanding or rendering of informed consent.
Any comorbidity that, in the opinion of the investigator, could compromise protocol objectives.
What this trial measures
- Agreement between PET-enabled DECT and X-ray DECT measurements of bone marrow tissue fractionsBaseline imaging visit; and for multiple myeloma participants, follow-up imaging at approximately Day +90 after CAR T-cell therapy initiation
Agreement between PET-enabled dual-energy CT and standard X-ray dual-energy CT will be assessed for quantitative bone fraction and soft-tissue fraction measurements in bone marrow regions.