Nicotinamide Riboside (Niagen®) and Brain Energy Metabolism

This study is looking at how a form of vitamin B3 called nicotinamide riboside (Niagen®) affects brain energy in healthy adults. Researchers want to see if taking 3000 mg of Niagen® daily for two weeks can increase the balance of two important brain chemicals, NAD+ and NADH. These chemicals are key to how your cells make and use energy. The main goal is to find out if this treatment changes the NAD+ to NADH ratio in your brain, which will be measured using special MRI scans. You might be able to join if you are a healthy adult between 18 and 65 years old, without a personal or close family history of mood or psychotic disorders. The study is currently unclear on its recruitment status and plans to enroll 50 participants.

Study design
This is a single-arm, open-label study, meaning all participants will receive the treatment and everyone will know what they are taking. It plans to include up to 50 healthy adults.
What's involved
You would take 12 capsules of Niagen® daily for two weeks. You will have two brain scans: one at the beginning of the study and one at the end (Day 15).
Compensation
Not stated in the trial record.
Follow-up
Participants will have a follow-up brain scan on Day 15, after two weeks of treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07649161

Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism

Recruiting
NAAges 18–65InterventionalTreatment
Massachusetts General Hospital
~50 participants
Updated 2026-06-17 on ClinicalTrials.gov
What's tested:Niagen®

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Brain NAD+/NADH Ratio
Measured over Participants will have two brain scans over the course of the study - one at baseline (Day 1) and one at follow up (Day 15)
Healthy Adult

NCT07649161

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Dauten Family Center for Bipolar Treatment Innovation

    Boston, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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  • Brain NAD+/NADH RatioParticipants will have two brain scans over the course of the study - one at baseline (Day 1) and one at follow up (Day 15)

    The investigators will be using a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) to measure NAD+ and NADH levels in the brain.