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Fresh Mango as a Sugar Replacement in Breakfasts

This study is looking at how replacing table sugar with fresh mango in high-sugar breakfasts affects your body. Researchers want to see if eating fresh mango instead of table sugar can reduce inflammation and improve your gut health after a meal. High-sugar meals can sometimes lead to inflammation and a "leaky gut" (when the gut barrier is disrupted), which might be linked to heart disease later on. This study will compare the effects of two breakfasts: corn flakes with milk and fresh mango, versus corn flakes with milk and table sugar. They will measure specific markers in your blood, like LPS, LPS Binding Protein, and IL-6, to see if the mango breakfast leads to lower levels of inflammation and better gut health. You can join if you are a healthy adult between 18 and 45 years old with a BMI between 18.5 and 35.0 kg/m2. The study is currently unclear on its recruitment status.

Study design
This is an interventional study involving 35 healthy participants. Each participant will try two different high-glycemic breakfasts in a random order.
What's involved
You will have an IV placed in your arm for blood draws. You will consume two different test meals and have blood samples collected at baseline, 30, 60, 120, and 180 minutes after each meal.
Compensation
Not stated in the trial record.
Follow-up
Blood markers will be measured through study completion, up to 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07650058

Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

Recruiting
NAAges 18–45Interventional
Ball State University
~35 participants
Updated 2026-06-16 on ClinicalTrials.gov
What's tested:High-Glycemic Breakfast Containing Cereal and Fresh MangoHigh-Glycemic Breakfast Containing Cereal and Table Sugar

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
LPS
Measured over Through study completion, up to 1 year.
+2 more outcomes measured

Conditions

Healthy Participants

Explore related trials

Healthy Participants

Where it's being run

1 sites across 1 states
Indiana1

Study leadership

  • Bryant Keirns, PhD · PRINCIPAL_INVESTIGATOR · Ball State University

Who to contact

Bryant Keirns, PhD
[email protected]
765-285-8356
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18 - 45 years.
Body mass index between 18.5-35.0 kg/m2
Not pregnant or expecting to become pregnant (females only)
Not postmenopausal (females only).
No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
No history of using tobacco/illicit drugs
No history of using glucose-lowering medications/supplements.
No history of using prescribed anti-inflammatory medications
Does not use over-the-counter anti-inflammatory medications ≥2x/week
Does not have a pacemaker.
No relevant food allergies/intolerances
Able to lay supine for at least ten minutes.

Exclusion

Not between the ages of 18-45
Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2
Pregnant (females only)
Postmenopausal status (females only).
Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
Uses tobacco products or any illicit drugs.
Uses glucose-lowering drugs/supplements.
Regularly takes anti-inflammatory drugs (more than 2x week).
Have a pacemaker.
Allergic to mango, wheat, gluten, and/or milk.
Unable to lay in supine position in the dark for at least ten minutes.

What this trial measures

  • LPSThrough study completion, up to 1 year.

    The investigators will measure LPS at baseline and 30-, 60-, 120-, and 180- minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

  • LPS Binding ProteinThrough study completion, up to 1 year.

    The investigators will measure LPS binding protein at baseline and 30-, 60-, 120-, and 180-minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

  • IL-6Through study completion, up to 1 year.

    The investigators will measure IL-6 at baseline and 30-, 60-, 120-, and 180-minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.