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Movie-Watching fMRI for Brain Tumor Patients

This study is comparing a new type of functional MRI (fMRI) called "naturalistic viewing" (or movie watching) with the standard fMRI used in clinics. Standard fMRI uses tasks like reading to find out which parts of your brain control language. This information helps surgeons plan brain operations. This research will see if the movie-watching fMRI works as well as, or better than, the standard method. If it does, it could make planning future surgeries easier for patients with glioma or adult brain tumors, as you wouldn't need to do multiple tasks during the scan. You can join if you are between 21 and 70 years old, speak English, have a known or suspected glioma, and are scheduled for a presurgical fMRI at BWH. The study aims to enroll 90 participants. The status of this study is currently unclear.

Study design
This is an interventional study with a planned enrollment of 90 participants. It compares two types of fMRI to see which is better for mapping brain function.
What's involved
You would participate in an additional study scan and undergo neuropsychological assessments, which are tests of your thinking and behavior.
Compensation
Not stated in the trial record.
Follow-up
The study will measure language localization, lateralization, and fMRI language activations concordance with language fiber tracts from enrollment up to 6 months after brain surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07650994

Movie-Watching Functional MRI for Mapping Brain Function in Neurosurgical Patients

Not Yet Recruiting
NAAges 21–70InterventionalDiagnostic
Brigham and Women's Hospital
~90 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Functional magnetic resonance imaging (fMRI)Neuropsychological Assessments

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Language localization
Measured over From enrollment to up to 6 months after brain surgery.
+2 more outcomes measured

Conditions

Glioma
Brain Tumor Adult

Explore related trials

Glioma

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Yanmei Tie, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

Who to contact

Yanmei Tie, PhD
[email protected]
617-378-2649
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Any sex, age between 21 to 70 years;
Known or suspected glioma (lesion) of the brain;
English speaking;
Patients with clinical fMRI scheduled (or pending scheduling) for presurgical planning at BWH ordered by a BWH clinician;
Passes prescreening and standard of care screenings for 3 Tesla MRI;
Willing to participate in the additional study scan and neuropsychological assessment visit;
Informed consent form signed by the subject or legally acceptable representative.

Exclusion

Contraindications to MRI: Note: MRI screening will be performed by radiology staff as part of their standard process for their clinical scans and if subjects do not pass the screen, MRI will not be performed.
Pregnancy or possible pregnancy: Female participants under 55 (or 45 with menstrual cycle in the past 12 months) who may be pregnant. Per policy: potential subjects will be asked if they are pregnant and excluded if they say yes. If unsure, pregnancy testing will be performed. Any subjects with positive result will be excluded.

What this trial measures

  • Language localizationFrom enrollment to up to 6 months after brain surgery.

    Sensitivity and specificity based on the proportion of activation within and outside of language regions-of-interest (ROIs).

  • Language lateralizationFrom enrollment to up to 6 months after brain surgery.

    Laterality index (LI) based on proportion of activation in the left vs. right hemisphere in language regions-of-interest (ROIs).

  • FMRI language activations concordance with language fiber tractsFrom enrollment to up to 6 months after brain surgery.

    Concordance with language fiber tracts identified by diffusion MRI in terms of the Euclidean distance between fMRI language activations and the tracts.