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NCT07653464

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Not Yet Recruiting
EARLY_PHASE1Ages 18–65InterventionalBasic science
University of Missouri-Columbia
~64 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:human insulin

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Amount of muscle sympathetic nerve activity (MSNA)
Measured over Change from baseline at minute 30
+2 more outcomes measured

Conditions

Obesity (BMI>30)
Insulin Resistance

Explore related trials

Insulin ResistanceObesity

Where it's being run

1 sites across 1 states
Missouri1

Who to contact

Jacqueline Limberg
[email protected]
573-882-2544
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Eligibility criteria

Inclusion

18 to 65 years of age
BMI 30-45 kg/m2
Waist circumference ≥102 cm (men) or ≥88 cm (women)
HOMA-IR ≥2.5
BMI 18-25 kg/m2
Waist circumference \<94 cm (men) and \<80 cm (women)
HOMA-IR \<2

Exclusion

Pregnancy, breastfeeding
Unable to provide consent
Diabetes or polycystic ovarian syndrome
Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
Nerve/neurologic disease
Uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>100 mmHg)
Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
Current smoking, tobacco, nicotine use
Use of pharmacological therapy for weight loss
Body weight change \>10% within the last 6 months
Adherence to \>150 min/week of moderate-to-vigorous physical activity/exercise
Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
Claustrophobia
Non-MRI compatible metal implants

What this trial measures

  • Amount of muscle sympathetic nerve activity (MSNA)Change from baseline at minute 30

    MSNA burst incidence (bursts/100 heart beats)

  • Amount of cerebral blood flowChange from baseline at minute 30

    Measured with arterial spin labeling (mL/100 g/min)

  • Amount of leg blood flowChange from baseline at minute 30

    Measured with Doppler ultrasound (mL/min)