NCT07653555
Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
Not Yet Recruiting
NAAges 1+InterventionalMayo ClinicInvestigator-initiated
~480 participants
Updated 2026-06-17 on ClinicalTrials.gov
What's tested:Cascade testingStandard of Care
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Genetic testing among first- and second-degree relatives within 12 months of index patient enrollment
Measured over 2 year
Conditions
Where it's being run
1 sites across 1 statesMinnesota1
Study leadership
- Elisa J. Houwink, MD, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Age ≥ 18 years.
Confirmed FH diagnosis using Dutch Lipid Clinic Network criteria \*or\* genetic confirmation.
Identified through REP or Tapestry databases.
Able and willing to provide informed consent.
At least one eligible first- or second-degree relative.
Access to and active use of email (computer literacy requirement).
First- or second-degree relative of an enrolled index patient.
Age ≥ 1 year (minors require parental consent + assent).
Willing to participate and able to complete electronic consent (guardian-assisted if minor).
Access to and active use of email (guardian).
Exclusion
No confirmed FH diagnosis.
Insufficient clinical follow-up (\<5 years).
No identifiable or contactable relatives.
Prior participation in structured cascade testing.
Severe cognitive impairment preventing informed consent.
Prior participation in structured cascade testing.
Severe cognitive impairment preventing informed consent.
What this trial measures
- Genetic testing among first- and second-degree relatives within 12 months of index patient enrollment2 year
Defined as total number of relations to complete CLIA-certified FH test (LDLR, APOB, PCSK9, LDLRAP1) with result returned to the primary care research team.