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DEPART Study for Dupuytren's Contracture

This study at Yale is testing if radiation therapy can help prevent Dupuytren's contracture (a condition where fingers bend into the palm) from getting worse or coming back. You might be able to join if you are over 30, speak English, and haven't had radiation on your affected hand before. The researchers will measure how much your fingers can straighten over several years to see if the radiation therapy is successful. The study aims to enroll 158 people, but its current recruitment status is unclear.

Study design
This is a randomized study, meaning participants are assigned to different groups by chance. It plans to enroll 158 participants.
What's involved
If you join, you would receive radiation therapy consisting of 10 treatments over a period that includes a 4-12 week break. You would also need to participate in follow-up appointments for at least 5 years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 108 months (9 years) after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07661342

DEPART Study at Yale

Not Yet Recruiting
PHASE3Ages 30+InterventionalTreatment
Yale University
~158 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Radiation Therapy

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants with Passive Extension Deficit (PED)
Measured over Day 0 (corresponding to the day of local treatment for intervention groups) and then at 6, 12, 24, 36, 48, 60, 84 and 108 months

Conditions

Dupuytren's Contracture

Explore related trials

Palmar Fibromatosis

NCT07661342

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Greenwich Hospital

    Greenwich, Connecticutno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Bruce McGibbon, MD · PRINCIPAL_INVESTIGATOR · Yale University
  • Frank D Buono, PhD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Bruce McGibbon, MD
[email protected]
203-8633-701
Email the study team

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Eligibility criteria

Inclusion

English-speaking
Patient consent
No previous radiotherapy to the affected hand
No history of radiation sensitivity diseases (e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni)
Age\>30
Life expectancy \>5 years
Available and willing to participate in at least 5 years of follow-up
Female patients capable of child-bearing that are not pregnant

Exclusion

Pregnancy or lactation
Known genetic disease that would make them extremely sensitive to radiation therapy, e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni

What this trial measures

  • Number of Participants with Passive Extension Deficit (PED)Day 0 (corresponding to the day of local treatment for intervention groups) and then at 6, 12, 24, 36, 48, 60, 84 and 108 months

    Deterioration greater than 20 degrees Passive Extension Deficit (PED) in any joint(s) of any of the affected digit(s) from post-intervention baseline in the presence of a palpable cord OR instigation of salvage surgical fasciectomy (SF) or NA to any of the affected digit(s).