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AYA-ONE: Exercise for Adolescent and Young Adult Sarcoma Survivors

This study, called AYA-ONE, is for adolescents and young adults (ages 15-39) who have been diagnosed with bone or soft tissue sarcoma. It aims to improve physical function and encourage exercise. The study will test a system to help match sarcoma survivors to the right exercise and rehabilitation services. You would first complete a tool called EXCEEDS to assess your physical function. If eligible, you would then receive a 12-week personalized exercise program, which might be supervised or unsupervised. The study will look at how well this system works and how your physical function and quality of life change. About 40 people are expected to join the first part of this study, and about 20 will complete the full program. The study is currently unclear on its recruitment status.

Study design
This is a single-arm pilot study, meaning all participants receive the intervention. It aims to enroll about 40 people in the first part and 20 in the full study.
What's involved
You would participate for about 6 months, which includes screening, completing the EXCEEDS tool, and potentially a 12-week personalized exercise program.
Compensation
Not stated in the trial record.
Follow-up
The study measures how quickly the triage tool is completed (at 2 weeks) and how quickly referrals are completed (within 2 months of EXCEEDS completion).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07662239

Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention

Recruiting
NAAges 15–39InterventionalSupportive care
Dana-Farber Cancer Institute
~40 participants
Updated 2026-08-26 on ClinicalTrials.gov
What's tested:Exercise Triage and Personalized Exercise Program

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Triage Tool Completion Rate
Measured over 2 weeks
+1 more outcome measured

Conditions

Sarcoma
Bone Sarcoma
Soft Tissue Sarcoma (STS)

Explore related trials

Bone SarcomaSoft Tissue Sarcoma

Where it's being run

3 sites across 1 states
Massachusetts3

Study leadership

  • Chao Cao, MD · PRINCIPAL_INVESTIGATOR · Dana-Farber Cancer Institute

Who to contact

Chao Cao, MD
[email protected]
617-632-4237
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosed with a bone or soft tissue sarcoma
Age 15-39 at time of diagnosis
Age 15 and older at time of enrollment
Age 15-17 at time of enrollment, with assent from participant and consent from parent/legal guardian
Established patient of the DFCI Sarcoma Center or Jimmy Fund
Able to read and understand English (to complete required questionnaires and participate in training/coaching)
Individuals who are not yet adults (teenagers) if they assent and their parents/legal guardians' consent to participation.

Exclusion

Unstable cardiovascular disease in the last 6 months
Psychiatric disorders or conditions that would preclude participation in the study intervention (e.g. untreated major depression or psychosis, untreated substance use disorder, severe personality disorder)
Pregnant
Currently participating in physical or occupational therapy
Presence of medical conditions or medications that would prohibit participation in an exercise program
Meeting exercise guidelines of 150 minutes of moderate intensity/75 minutes of vigorous intensity physical activity per week plus consistent strength training (at least once per week) over the past 3 months. Assessed via Godin Leisure Time Questionnaire by study staff.
Adults unable to consent

What this trial measures

  • Triage Tool Completion Rate2 weeks

    Triage tool completion rate is defined as the proportion of consented participants who fully completed the Exercise in Cancer Evaluation and Decision Support (EXCEEDS) tool.

  • Referral Completion RateWithin 2 months of EXCEEDS completion

    Referral completion rate is defined as the rate of participants who completed the EXCEEDS tool and subsequently completed an initial visit with an occupational therapist (OT), physical therapist (PT), trainer, or health coach.