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Exercise for Lower Limb Recovery After Stroke

This study is looking at how a specific exercise program, called High-Intensity Interval Training (HIIT), can help people who have had a subcortical stroke (a type of stroke affecting a specific part of the brain) and have difficulty walking. You might be able to join if you are 18-80 years old, had a stroke at least six months ago, and walk slower than 0.6 meters per second. The study involves 12 weeks of cycling exercises three times a week at Emory University. Researchers want to see if this exercise improves your walking speed. The study aims to enroll 55 participants, but the current recruitment status is unclear.

Study design
This is an interventional study involving 55 participants with chronic subcortical stroke. It tests a High-Intensity Interval Training (HIIT) intervention.
What's involved
You would participate in 36 cycling sessions over 12 weeks, three times a week for 25-60 minutes each. There will also be pre-, during-, and post-intervention measurements, including blood lactate measurements via finger pricks during some sessions.
Compensation
Not stated in the trial record.
Follow-up
Your walking speed will be measured at 12 weeks post-intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07663292

Neuroplastic Changes Due to an Exercise Intervention That Aid in Lower Limb Recovery After Subcortical Stroke

Recruiting
NAAges 18–80InterventionalSupportive care
Emory University
~55 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:HIIT intervention

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Walking Speed Assessed by the 10-Meter Walk Test (10MWT)
Measured over 12 weeks post-intervention

Conditions

Subcortical Lesions
Stroke

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Stroke

NCT07663292

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Emory Rehabilitation Hospital

    Atlanta, Georgiastudy coordinator listed

    Recruiting

  • Emory University Hospital

    Atlanta, Georgiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Lisa Krishnamurthy, PhD · PRINCIPAL_INVESTIGATOR · Emory University

Who to contact

Lisa Krishnamurthy, PhD
[email protected]
404-712-5332
Email the study team

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Eligibility criteria

Inclusion

chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident
lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk,
age 18-80 years old, and
Screen pass of the Stress test or Physician sign-off from the participant's health care team that they are cleared for a 12 week exercise intervention

Exclusion

MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia
any neurodegenerative condition other than stroke that may lead to lower extremity impairment
visual or auditory impairment that may hinder study procedures, and
any medical condition that would preclude from participation in a physical exercise intervention program.

What this trial measures

  • Walking Speed Assessed by the 10-Meter Walk Test (10MWT)12 weeks post-intervention

    Walking speed will be measured using the 10-Meter Walk Test (10MWT). Participants will be instructed to walk a measured 10-meter distance at their comfortable walking speed. The time required to traverse the designated distance will be recorded using a stopwatch, and walking speed will be calculated as distance divided by time and expressed in meters per second (m/s). Higher values indicate faster walking speed and improved ambulatory function.