Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
This study is looking at a non-surgical brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS). TIEFS uses electrical currents applied to the scalp to see how it affects brain activity and thinking. We want to understand how TIEFS changes brain signals, if it impacts abilities like memory or language, and if it's safe. Adults aged 18 to 65 can join. This includes people with epilepsy who are already having brain monitoring, and healthy volunteers. The study aims to see changes in brain activity during stimulation, which will be measured throughout the session (up to 90 minutes). The study is currently unclear on its recruitment status and plans to enroll 15 participants.
- Study design
- This is an interventional study, but the phase is not specified. It plans to enroll 15 participants, including adults with epilepsy and healthy volunteers.
- What's involved
- Measurements will be recorded throughout the stimulation session, which lasts up to 90 minutes. Data will be collected before, during, and immediately after each stimulation.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be recorded throughout the stimulation session, with data collected before, during, and immediately after each stimulation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
At a glance
Conditions
NCT07663578
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of California Davis Medical Center
Sacramento, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Nigel P Pedersen, MBBS · PRINCIPAL_INVESTIGATOR · University of California Davis, School of Medicine, Neurology Department
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Want this trial checked against your situation?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Brain activity changes during StimulationMeasurements will be recorded throughout the stimulation session (lasting up to 90 minutes), with data collected before, during, and immediately after each stimulation.
This outcome measures the changes in brain activity, either measured through scalp EEG electrodes (in Healthy Participant controls), or intracranial stereotaxic EEG electrodes (for SEEG pre-surgical evaluation epilepsy patients). Local field potential (LFP) power and EEG power in response to active TIEFS stimulation will be compared to sham stimulation. Electrical signals recorded from the brain reflect neural activity. Intracranial signals will be measured across different locations in the brain using implanted SEEG electrodes. Additionally, SEEG electrodes may have tetrodes tips to capture single neuron activity. We will compare how the brain's electrical activity changes during active TIEFS at various frequencies and during the sham stimulation to assess the impact on brain and neural function.