This study is looking at how to best set ventilators for patients with severe lung injury, called Acute Respiratory Distress Syndrome (ARDS), who are also on Extracorporeal Membrane Oxygenation (ECMO), sometimes called a heart-lung machine. While ventilators help you breathe, they can sometimes cause more lung damage. ECMO helps reduce this damage, but doctors aren't sure of the best ventilator settings to use while on ECMO. This study will compare a personalized ventilator setting, called Personalized Positive End-Expiratory Pressure (PEEP), to the usual ventilator settings. Researchers will measure inflammation (IL-6 and sRAGE), breathing effectiveness, and lung mechanics to see if personalized settings reduce lung injury. You may be able to join if you are 18 or older and meet other specific criteria.

Study design

This is an interventional study planning to enroll 62 participants. Participants will be randomly assigned to receive either personalized ventilator settings or standard ventilator settings.

What's involved

Participants will have measurements taken at the start of the study, then at 24, 48, and 72 hours after enrollment, and at the end of their ECMO treatment.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed until the end of their ECMO run.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.