Transcutaneous Spinal Stimulation for Blood Pressure Control in Spinal Cord Injury

This study is investigating whether transcutaneous spinal stimulation, which involves applying electrical stimulation to the spinal cord through the skin, can help manage blood pressure in people with spinal cord injuries. Researchers want to see if this stimulation has immediate effects on blood pressure and if it can lead to lasting improvements, especially for orthostatic hypotension (a drop in blood pressure when moving from lying down to sitting or standing). You might be able to join if you are 18-75 years old, have had a spinal cord injury for at least one year, and experience persistent low blood pressure or orthostatic hypotension. The study aims to enroll 10 participants and will measure changes in systolic blood pressure to see if the treatment is successful.

Study design
This interventional study plans to enroll 10 participants to test the effects of transcutaneous spinal stimulation.
What's involved
You would undergo a tilt test with stimulation and participate in 20 separate 30-minute sessions of transcutaneous spinal cord stimulation while seated.
Compensation
Not stated in the trial record.
Follow-up
Your systolic blood pressure will be measured at 1 month and again through study completion, which is an average of 5 months.

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NCT07674511

Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury

Not Yet Recruiting
NAAges 18–75InterventionalTreatment
Kessler Foundation
~10 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Tilt test with stimulation (real-time effects): Intervention 120 sessions of stimulation (Intervention 2)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Systolic blood pressure
Measured over 1 month
+1 more outcome measured
Spinal Cord Injuries
Hypotension
Orthostatic Hypotension
Spinal Cord Diseases
Cardiovascular Diseases
Trauma, Nervous System
Central Nervous System Disease
Nervous System Diseases
Blood Pressure
1 sites across 1 states
New Jersey1
  • Gail F Forrest, PhD · PRINCIPAL_INVESTIGATOR · Kessler Foundation

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Eligibility criteria

Inclusion

Individuals with a SCI ≥ 1 year after injury
Injury level ≥ T6 (thoracic level)
AIS grade A-C
Cardiovascular dysfunction characterized by one or more of the following:

Exclusion

Current illness (e.g., infection, a pressure injury that might interfere with the intervention)
Ventilator-dependent
History of implanted brain/spine/nerve stimulators
Cardiac pacemaker/defibrillator or intra-cardiac lines
Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction
History of seizures
pregnancy
Insufficient mental capacity to understand and independently provide consent
Deemed unsuitable by the study physician
  • Systolic blood pressure1 month

    Evaluate changes in blood pressure during an orthostatic tilt test comparing stimulation to no stimulation.

  • Systolic blood pressureThrough study completion, an average of 5 months

    changes in blood pressure drop with tilt (no stimulation) from baseline testing to tilt test (no stimulation) after 20 sessions of stimulation