Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

This study is looking at how a medication called Gemtesa affects blood flow in aging women. Researchers want to see if Gemtesa, which targets certain receptors (beta3 adrenergic receptors) in the body, can improve blood vessel function. You might be able to join if you are a healthy woman between 18 and 70 years old, assigned female at birth, and meet specific body mass index (BMI) requirements. You cannot participate if you are pregnant, breastfeeding, or have a history of hormone replacement therapy, certain ovarian conditions, or currently smoke. The main goal is to measure changes in blood flow from the beginning of the study to two minutes after receiving the treatment. The study is currently unclear about its recruitment status and plans to enroll 60 participants.

Study design
This is an interventional study, meaning participants will receive either Gemtesa or a placebo (an inactive pill). It plans to enroll 60 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Blood flow will be measured at two minutes after treatment to assess the primary outcome.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07674680

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

Not Yet Recruiting
EARLY_PHASE1Ages 18–70InterventionalBasic science
University of Missouri-Columbia
~60 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:PlaceboGemtesa

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood flow
Measured over Change from baseline to minute 2.
Women
Aging
Menopause
1 sites across 1 states
Missouri1
Jacqueline Limberg Associate Professor
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy women,
Assigned female at birth,
18-70 years of age,
Body mass index \<18 or ≥30 kg/m2,

Exclusion

Assigned male at birth,
Pregnancy,
Breastfeeding,
History of hormone replacement therapy, chemical menopause, or oophor-ectomy
Polycystic ovarian syndrome or Primary ovarian insufficiency,
Current smoking/Nicotine use,
Blood pressure ≥140/90 mmHg,
Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy,
Nerve/neurologic disease,
Cardiovascular, hepatic, renal, respiratory disease,
Hypersensitivity to nitroglycerin,
Diabetes,
Communication barriers,
  • Blood flowChange from baseline to minute 2.

    Blood flow measured with Doppler ultrasound.