Observational Study on Heart Dysfunction in Muscular Dystrophy

This study is looking at heart problems (cardiomyopathy) in people with Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and carriers of these conditions. Heart problems are a major cause of death in these diseases, but doctors don't fully understand how they develop. This study aims to learn more about how heart dysfunction progresses and to find ways to predict who might be at higher risk for severe heart disease or death using heart MRI images. The goal is to create tools that can help doctors worldwide. You may be able to join if you have DMD, BMD, or are a carrier, confirmed by a muscle biopsy or genetic test. The study will track outcomes like mortality (death) over 10 years.

Study design
This is an observational study, meaning researchers will watch and collect information without giving any specific interventions. It plans to include 1000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for mortality from the start of the study up to 10 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07674758

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials

Recruiting
Not specifiedAll AgesObservational
Vanderbilt University Medical Center
~1,000 participants
Updated 2026-07-28 on ClinicalTrials.gov

At a glance

Recruiting sites
9 of 9 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mortality
Measured over baseline to 10 years
Duchenne Muscular Dystrophy (DMD)
Cardiomyopathy
Becker Muscular Dystrophy
Carrier of Duchenne Muscular Dystrophy

NCT07674758

Where you'd take part

This study runs at 9 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Children's Hospital of Richmond at VCU

    Richmond, Virginiastudy coordinator listed

    Recruiting

  • Children's National

    Washington D.C., District of Columbiastudy coordinator listed

    Recruiting

  • Duke Children's Hospital

    Durham, North Carolinastudy coordinator listed

    Recruiting

  • Lurie Children's

    Chicago, Illinoisstudy coordinator listed

    Recruiting

  • Nationwide Children's

    Columbus, Ohiostudy coordinator listed

    Recruiting

  • Riley Children's Hospital

    Indianapolis, Indianastudy coordinator listed

    Recruiting

  • Seattle Children's

    Seattle, Washingtonstudy coordinator listed

    Recruiting

  • UC Davis

    Sacramento, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Clinical phenotype of Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or muscular dystrophy carrier (MDC) confirmed with muscle biopsy or genotype

Exclusion

Additional genetic or congenital abnormality that may affect cardiovascular function or progression
Current investigational therapy that may affect cardiovascular function (would preclude ongoing data collection but prior data would still be used)
  • Mortalitybaseline to 10 years

    Time from biomarker of interest to mortality