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Understanding Oxygen Delivery in Preterm Infants on CPAP

This study aims to understand how different levels of breathing support, called nasal continuous positive airway pressure (nCPAP), affect how much oxygen preterm babies actually receive and how well their lungs expand. Researchers will measure oxygen delivery and lung expansion using a catheter in the baby's throat and soft bands around their chest. The goal is to learn if the oxygen amount ordered by a doctor on the nCPAP machine changes by the time it reaches the baby's airway, and if this changes with different air pressure settings. This study is for preterm infants born before 35 weeks who are stable on nCPAP and receiving 22-40% oxygen. There are 10 planned participants.

Study design
This interventional study will involve 10 preterm infants. It is not specified if the study is randomized or blinded.
What's involved
You would need to allow for a catheter to be placed in your infant's throat and soft bands to be wrapped around their chest. Measurements will occur at three separate points within a thirty-minute timeframe.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07674953

How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants

Recruiting
NAAll AgesInterventionalSupportive care
University of Arkansas
~10 participants
Updated 2026-06-30 on ClinicalTrials.gov
What's tested:Effective oxygen delivery and lung expansion measurement

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inspired Oxygen
Measured over Sampling will occur at three separate points within a thirty minute time frame for each enrolled infant.

Conditions

Respiratory Distress Syndrome (Neonatal)
Respiratory Distress of Newborn

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NCT07674953

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansasstudy coordinator listed

    Not yet recruiting

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Nicholas A Rowley, MD
[email protected]
940-230-5002
Email the study team

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Eligibility criteria

Inclusion

Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical
The infant must be stable while receiving nasal CPAP at any pressure level at the time of study
The infant must be receiving 22-40% at the time of the study

Exclusion

Oxygen requirements greater than 40% at time of enrollment
currently receiving invasive ventilation or not requiring ventilatory support
Major congenital anomalies of the heart and/or lungs

What this trial measures

  • Inspired OxygenSampling will occur at three separate points within a thirty minute time frame for each enrolled infant.

    Percent of oxygen delivered to the back of the infant's mouth. This will be measured by placing a small plastic tube in the back of the infant's mouth and sampling the air while the infant is receiving several different pressure levels of CPAP.