UHFUS Characterization of Normal Lymphatic Anatomy in Breast Cancer Patients

This study is looking at how lymphatic channels (small vessels that carry fluid and immune cells) appear in people with breast cancer using a special type of ultrasound called Ultra-High Frequency Ultrasound (UHFUS). Researchers will inject a dye called Indocyanine green (ICG) solution into your hand and wrist. Then, they will use UHFUS to take pictures of your lymphatic channels between your wrist and elbow. The main goal is to measure the size of these lymphatic channels. You may be able to join if you are 18 or older, have been diagnosed with breast cancer, and are planning to have surgery called axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB). This study is currently unclear regarding its recruitment status and plans to enroll 50 participants.

Study design
This is a pilot study involving 50 participants with breast cancer. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
You would receive an injection of Indocyanine green (ICG) solution in your hand and wrist. Then, Ultra-High Frequency Ultrasound (UHFUS) will be used to capture images of your lymphatic channels.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, outer lymphatic vessel diameter, is measured during ultra-high frequency ultrasound imaging. No further follow-up is specified.

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NCT07677839

UHFUS Characterization of Normal Lymphatic Anatomy

Recruiting
NAAges 18+InterventionalDiagnostic
University of California, Davis
~50 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Indocyanine green (ICG) solution injectionUltra-High Frequency Ultrasound

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Outer lymphatic vessel diameter
Measured over During ultra-high frequency ultrasound imaging
Breast Cancer
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

1\. Aged 18+ at the time of consent.
2\. Confirmed breast cancer diagnosis
3\. Planned ALND (CPT code: 38745) or SLNB (CPT code: 38900) for breast cancer treatment
4\. Provision of a signed and dated informed consent form.
5\. Stated willingness to comply with all study procedures and availability for the duration of the study.

Exclusion

1\. History of transient or permanent edema of the extremity, including edema ≥stage 1 per the International Society of Lymphology (ISL) staging system 15
2\. History of prior axillary nodal surgery
3\. History of any lymphatic disease or venous disease of the upper extremity, including deep venous thrombosis
  • Outer lymphatic vessel diameterDuring ultra-high frequency ultrasound imaging

    Total diameter including wall and lumen