Cannabis and Brain Activity Study
This study looks at how cannabis affects memory in regular users. Researchers are observing how different strains of smoked cannabis flower (one with THC, and another with both THC and CBD) impact your recognition memory. You would complete memory tasks after using cannabis and again when not intoxicated. The study measures your brain waves using an electroencephalogram (EEG) during these tasks. To join, you need to be between 21 and 40 years old, right-handed, and use cannabis at least 4 days a month for at least a year. The main goal is to see how cannabis changes brain wave patterns and memory accuracy. The current status of this study is unclear.
- Study design
- This is an observational study with 64 planned participants. It compares your brain activity and memory when you are intoxicated with cannabis versus when you are not.
- What's involved
- You will complete recognition memory tasks after self-administering cannabis on one day and again on another day when not intoxicated. Blood will be collected, and you will complete several questionnaires about your health and habits.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your brain wave patterns and memory accuracy will be measured at an intoxicated session and a not-intoxicated session, about one week apart.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 4
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Timothy Curran, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Colorado, Boulder
Who to contact
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What this trial measures
- Difference in ERP amplitude (FN400)Intoxicated session and not-intoxicated session (about 1 week)
The FN400 event-related potential (ERP) old/new effect will be measured using electroencephalography (EEG) during a recognition memory test. The FN400 reflects familiarity-based memory retrieval and is defined as the mean ERP amplitude difference between correctly recognized previously presented items ("hits") and correctly rejected novel items ("correct rejections") at mid-frontal electrode sites during the 300-500ms post-stimulus interval.
- Difference in ERP amplitude (parietal)Intoxicated session and not-intoxicated session (about 1 week)
The parietal ERP old/new effect will be measured using EEG during a recognition memory test. The parietal old/new effect reflects recollection-based memory retrieval and is defined as the mean ERP amplitude difference between hits and correct rejections at parietal electrode sites during the 500-800ms post-stimulus interval.
- Difference in retrieval memory accuracyIntoxicated session and not-intoxicated session (about 1 week)
Behavioral accuracy during recognition memory test will be assessed by the number of hits and correct rejections made during memory recall. Retrieval memory accuracy will be compared between intoxicated and not-intoxicated sessions.
- Difference in retrieval memory performanceIntoxicated session and not-intoxicated session (about 1 week)
Memory performance will be assessed via reaction time, measured by a photocell during recognition memory testing and concurrent EEG. During the recall phase, a light indicator will appear in the bottom-right corner of the stimulus screen when a prompted image is presented, activating the photocell. This indicator disappears once the participant responds. The interval between stimulus onset and the participant's "new" or "old" response is used as the reaction time measure for both intoxicated and non-intoxicated sessions. Retrieval memory performance will be compared between intoxicated and not-intoxicated sessions.