Phosphate in Acute Pancreatitis Study
This study at Duke University Hospital is looking into whether giving phosphate through an IV can help adults with acute pancreatitis (inflammation of the pancreas). Researchers want to see if low phosphate levels make pancreatitis worse and if giving Sodium Phosphate or Potassium Phosphate can make the illness less severe. They are also trying to figure out the best dose and if this treatment is practical to use. You might be able to join if you are 18 or older and come to the emergency department with acute pancreatitis symptoms, like severe abdominal pain or high lipase/amylase levels. The study will measure your serum phosphorus levels and how severe your disease is to see if the treatment is successful. The current status of the study is unclear.
- Study design
- This is a two-phase pilot study involving 100 adult patients with acute pancreatitis. The first phase is observational, and the second phase involves a treatment group.
- What's involved
- If you are in the treatment group, you would receive continuous intravenous infusions of Sodium Phosphate or Potassium Phosphate for up to 72 hours. Your serum phosphorus levels will be measured during your hospitalization, up to about 7 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your disease severity and serum phosphorus levels will be measured during hospitalization, up to approximately 7 days.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Phosphate in Acute Pancreatitis
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Samuel Francis, MD · PRINCIPAL_INVESTIGATOR · Duke University Hospital
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Serum Phosphorus LevelsDuring hospitalization, up to approximately 7 days
Serum phosphorus levels measured in a control (observational) group of patients with acute pancreatitis. This will be determined utilizing the Revised Atlanta Classification.
- Disease Severity as measured by the Revised Atlanta Classification (RAC)During hospitalization, up to approximately 7 days
The RAC is categorized into three levels based on the absence or presence of organ failure and local or systemic complications: Mild = No organ failure and no local or systemic complications, Moderately Severe = Transient organ failure (resolving within 48 hours) OR local/systemic complications without persistent organ failure, Severe = Persistent organ failure (lasting more than 48 hours) that can involve a single or multiple organ systems.